The Usefulness of Ultrasonography for Supporting the Differentiation, Diagnosis, and Treatment of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma

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dc.contributor.authorCrisan, Diana
dc.contributor.authorSchneider, Lars Alexander
dc.contributor.authorScharffetter-Kochanek, Karin
dc.contributor.authorBernhard, Lukas
dc.contributor.authorCrisan, Maria
dc.contributor.authorWortsman, Ximena
dc.date.accessioned2025-01-20T16:19:35Z
dc.date.available2025-01-20T16:19:35Z
dc.date.issued2024
dc.description.abstractAtypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare histomorphological variants of a disease spectrum. After ruling out other tumor entities by immunohistochemistry, PDS can be differentiated from AFX by infiltration into the subcutis, while AFX remains confined to the dermis. The therapeutic approach is more aggressive in PDS as it can potentially metastasize. We assessed the usefulness of preoperative sonography in differentiating between the two tumor entities by identifying a potential subcutaneous infiltration. In our patients (n = 13), preoperative sonography identified and differentiated AFX and PDS with 100% accuracy and even changed the initial histological suspicion of AFX to PDS in 3 cases (23%), which was confirmed after tumor resection. Preoperative sonography of these tumors could strengthen the clinical diagnosis, avoid a delay in therapy initiation and improve patient counseling. While for AFX, micrographic-controlled surgery suffices, for PDS, resection with 2 cm safety margins and lymph node sonography to rule out lymphonodal involvement is necessary. Hence, ultrasonography can improve clinical practice by providing helpful information for dermatosurgeons, which cannot be obtained during clinical examination.
dc.description.funderDEAL
dc.fuente.origenWOS
dc.identifier.doi10.1002/jum.16478
dc.identifier.eissn1550-9613
dc.identifier.issn0278-4297
dc.identifier.urihttps://doi.org/10.1002/jum.16478
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90697
dc.identifier.wosidWOS:001214072300001
dc.issue.numero8
dc.language.isoen
dc.pagina.final1572
dc.pagina.inicio1563
dc.revistaJournal of ultrasound in medicine
dc.rightsacceso restringido
dc.subjectcutaneous sarcoma
dc.subjectdermatologic surgery
dc.subjectinfiltration depth
dc.subjectultrasonography
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Usefulness of Ultrasonography for Supporting the Differentiation, Diagnosis, and Treatment of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma
dc.typeartículo
dc.volumen43
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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