Arsenic in drinking water and prostate cancer: A population-based case-control study in Northern Chile

Simple item page
dc.catalogadorjlo
dc.contributor.authorSchwalb, Molly E.
dc.contributor.authorFerreccio Readi, Catterina
dc.contributor.authorBlanco, Estela
dc.contributor.authorSmith, Allan H.
dc.contributor.authorSteinmaus, Craig
dc.date.accessioned2025-12-10T15:00:29Z
dc.date.available2025-12-10T15:00:29Z
dc.date.issued2025
dc.description.abstractBackground: Epidemiologic evidence demonstrates increased lung, bladder, and skin cancer riskamong individuals exposed to arsenic in drinking water. Some studies report associations withprostate cancer, but data are limited. This study aimed to examine the association between arsenicin drinking water and prostate cancer in Northern Chile. With its wide range of exposure (<10–860μg/L), large population, and accurate information on historical exposures, Northern Chile is thebest place to investigate the human carcinogenic effects of arsenic.Methods: A case-control study conducted from 2015–2019 enrolled 343 prostate cancer casesand 337 age-matched controls among men aged ≥40 years. Cases were ascertained from cancercommittees, hospitals, and medical facilities in the area. Controls were ascertained from the ChileVoter Registry, including >90% of adults aged >50 years. Information on lifetime arsenic exposureand potential confounders such as smoking, family history, and prostate cancer screening werecollected.Results: Twenty-three percent of participants were exposed to arsenic concentrations >800 μg/Lin their lifetime (80x recommended thresholds). Cases and controls were demographically similar.After adjustment for age and smoking status, participants with the highest quartile of lifetimecumulative and average arsenic concentrations in drinking water each had 1.14 (95%CI 0.71–1.84)and 1.17 (95%CI 0.73–1.89) times the odds of prostate cancer compared to participants with thelowest quartile of exposure, respectively.Conclusions: Arsenic exposure in drinking water, even at high levels, was not associated withincreased risk of prostate cancer.
dc.format.extent14 páginas
dc.fuente.origenSIPA
dc.identifier.doi10.1158/1055-9965.EPI-25-0834.
dc.identifier.urihttps://doi.org/10.1158/1055-9965.EPI-25-0834
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107330
dc.information.autorucEscuela de Medicina; Ferreccio Readi, Fresia Catterina; 0000-0001-6331-5534; 99684
dc.information.autorucS/I; Blanco, Estela; 0000-0002-6232-9210; 1232774
dc.issue.numero12
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final2207
dc.pagina.inicio2201
dc.revistaCancer Epidemiology Biomarkers & Prevention
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.ods06 Clean water and sanitation
dc.subject.odspa06 Clean water and sanitation
dc.titleArsenic in drinking water and prostate cancer: A population-based case-control study in Northern Chile
dc.typeArtículo
dc.volumen34
sipa.codpersvinculados99684
sipa.codpersvinculados1232774
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Schwalb M 2025_prostate.pdf
Size:
348.87 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas