AGE AND CASTRATION MODULATE THE INHIBITORY-ACTION OF NEUROPEPTIDE-Y ON NEUROTRANSMISSION IN THE RAT VAS-DEFERENS

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dc.contributor.authorBITRAN, M
dc.contributor.authorTORRES, G
dc.contributor.authorFOURNIER, A
dc.contributor.authorSTPIERRE, S
dc.contributor.authorHUIDOBROTORO, JP
dc.date.accessioned2025-01-23T19:22:31Z
dc.date.available2025-01-23T19:22:31Z
dc.date.issued1991
dc.description.abstractThe potency of neuropeptide Y (NPY) to inhibit the electrically induced contractions of the epididymal half of the vas deferens diminishes markedly with age, being at least 20 times lower in the adult than in the 26-day-old rat. Castration sensitizes the epididymal segment to NPY in a testosterone-reversible manner. [Pro34]NPY was 3 times less potent than NPY in prepubertal rats and inactive in castrated adults, while NPY-(13-36) had no effect in either group. In the prostatic half, NPY and its analogs were active in rats from all ages studied; the order of potency being NPY > [Pro34]NPY > NPY-(13-36). The sensitivity of the prostatic segment from adult rats to NPY was unchanged by castration or testosterone replacement therapy. The NPY content of the ductus increases during development being higher in,the prostatic than in the epididymal half at all ages studied. Castration decreases the peptide content in the two segments and the effect is prevented by testosterone administration. The present investigation demonstrated that the effect of NPY on vas deferens neurotransmission is subject to regulation by sex steroids, which affects differently the response of the two segments of the ductus.
dc.fuente.origenWOS
dc.identifier.issn0014-2999
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99052
dc.identifier.wosidWOS:A1991GN50200014
dc.issue.numero2
dc.language.isoen
dc.pagina.final274
dc.pagina.inicio267
dc.revistaEuropean journal of pharmacology
dc.rightsacceso restringido
dc.subjectNEUROPEPTIDE-Y (NPY)
dc.subjectVAS DEFERENS
dc.subjectNEUROTRANSMISSION
dc.subjectHORMONAL REGULATION
dc.subjectCASTRATION NEUROTRANSMISSION
dc.subject(AGE AND CASTRATION)
dc.subject(RAT)
dc.subject.ods02 Zero Hunger
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa02 Hambre cero
dc.subject.odspa03 Salud y bienestar
dc.titleAGE AND CASTRATION MODULATE THE INHIBITORY-ACTION OF NEUROPEPTIDE-Y ON NEUROTRANSMISSION IN THE RAT VAS-DEFERENS
dc.typeartículo
dc.volumen203
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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