Gastrointestinal symptoms and complications in patients hospitalized due to COVID-19, an international multicentre prospective cohort study (TIVURON project)

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dc.contributor.authorCardenas-Jaen, Karina
dc.contributor.authorSanchez-Luna, Sergio A.
dc.contributor.authorVaillo-Rocamora, Alicia
dc.contributor.authorCastro-Zocchi, Micaela Riat
dc.contributor.authorGuberna-Blanco, Laura
dc.contributor.authorUseros-Branas, Daniel
dc.contributor.authorRemes-Troche, Jose M.
dc.contributor.authorRamos-De la Medina, Antonio
dc.contributor.authorPriego-Parra, Bryan A.
dc.contributor.authorVelasco, Jose A. Velarde-Ruiz
dc.contributor.authorMartinez-Ayala, Pedro
dc.contributor.authorUrzua, Alvaro
dc.contributor.authorGuinez-Francois, Dannette
dc.contributor.authorPawlak, Katarzyna M.
dc.contributor.authorKozlowska-Petriczko, Katarzyna
dc.contributor.authorGorrono-Zamalloa, Irati
dc.contributor.authorUrteaga-Casares, Clara
dc.contributor.authorOrtiz-Polo, Inmaculada
dc.contributor.authorAntonana, Adolfo del Val
dc.contributor.authorLozada-Hernandez, Edgard E.
dc.contributor.authorObregon-Moreno, Enrique
dc.contributor.authorGarcia-Rayado, Guillermo
dc.contributor.authorDomper-Arnal, Maria Jose
dc.contributor.authorCasas-Deza, Diego
dc.contributor.authorEsteban-Cabello, Elena I.
dc.contributor.authorDiaz, Luis A.
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorMartinez-Lozano, Helena
dc.contributor.authorNavarro-Romero, Francisco
dc.contributor.authorOlivas, Ignasi
dc.contributor.authorIborra-Munoz, Guillem
dc.contributor.authorCalero-Amaro, Alicia
dc.contributor.authorCaravaca-Garcia, Iban
dc.contributor.authorLacueva-Gomez, Francisco J.
dc.contributor.authorPastor-Mateu, Ruben
dc.contributor.authorLapena-Munoz, Berta
dc.contributor.authorSastre-Lozano, Violeta
dc.contributor.authorPizarro-Vega, Nazaret M.
dc.contributor.authorMelcarne, Luigi
dc.contributor.authorPedrosa-Aragon, Marc
dc.contributor.authorMira, Jose J.
dc.contributor.authorMStat, Aurora Mula
dc.contributor.authorCarrillo, Irene
dc.contributor.authorde-Madaria, Enrique
dc.date.accessioned2025-01-20T20:09:18Z
dc.date.available2025-01-20T20:09:18Z
dc.date.issued2023
dc.description.abstractBackground: Retrospective studies suggest that coronavirus disease (COVID-19) commonly involves gastrointestinal (GI) symptoms and complications. Our aim was to prospectively eval-uate GI manifestations in patients hospitalized for COVID-19.
dc.description.abstractMethods: This international multicentre prospective cohort study recruited COVID-19 patients hospitalized at 31 centres in Spain, Mexico, Chile, and Poland, between May and September 2020. Patients were followed-up until 15 days post-discharge and completed comprehensive questionnaires assessing GI symptoms and complications. A descriptive analysis as well as a bivariate and multivariate analysis were performer using binary logistic regression. p < 0.05 was considered significant.
dc.description.abstractResults: Eight hundred twenty-nine patients were enrolled; 129 (15.6%) had severe COVID-19, 113 (13.7%) required ICU admission, and 43 (5.2%) died. Upon admission, the most prevalent GI symptoms were anorexia (n = 413; 49.8%), diarrhoea (n = 327; 39.4%), nausea/vomiting (n = 227; 27.4%), and abdominal pain (n = 172; 20.7%), which were mild/moderate throughout the disease and resolved during follow-up. One-third of patients exhibited liver injury. Non-severe COVID-19 was associated with >= 2 GI symptoms upon admission (OR 0.679; 95% CI 0.464-0.995; p = 0.046) or diarrhoea during hospitalization (OR 0.531; 95% CI 0.328-0.860; p = 0.009). Multivariate analysis revealed that worse hospital outcomes were not independently associated with liver injury or GI symptoms.
dc.description.abstractConclusion: GI symptoms were more common than previously documented, and were mild, rapidly resolved, and not independently associated with COVID-19 severity. Liver injury was a frequent complication in hospitalized patients not independently associated with COVID-19 severity. (c) 2022 The Authors. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.gastrohep.2022.10.007
dc.identifier.issn0210-5705
dc.identifier.urihttps://doi.org/10.1016/j.gastrohep.2022.10.007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91985
dc.identifier.wosidWOS:001004644600001
dc.issue.numero6
dc.language.isoen
dc.pagina.final438
dc.pagina.inicio425
dc.revistaGastroenterologia y hepatologia
dc.rightsacceso restringido
dc.subjectCOVID-19
dc.subjectGastrointestinal symptoms
dc.subjectGastrointestinal complications
dc.subjectHospitalization
dc.subjectHepatitis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGastrointestinal symptoms and complications in patients hospitalized due to COVID-19, an international multicentre prospective cohort study (TIVURON project)
dc.typeartículo
dc.volumen46
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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