EPINEPHRINE DECREASES THE POTASSIUM REQUIREMENTS OF HAMSTER SPERM CAPACITATION - FUROSEMIDE BLOCKS THE EFFECT OF EPINEPHRINE

Simple item page
dc.contributor.authorBIZE, I
dc.contributor.authorSANTANDER, G
dc.date.accessioned2025-01-23T19:27:23Z
dc.date.available2025-01-23T19:27:23Z
dc.date.issued1985
dc.description.abstractThe possibility of an interaction between epinephrine and external K in the stimulation of the hamster sperm acrosome reaction and in vitro fertilizing ability were investigated. K+ is required late in capacitation and/or the acrosome reaction, but is not required for penetration of the zona pellucidae. The presence of epinephrine (50 .mu.M) in the capacitation medium lowers the K+ requirements of these processes and furosemide, a cotransport inhibitor, blocks the acrosome reaction, in vitro fertilization, and inhibits the stimulation by epinephrine. These results support the idea that there is an interaction between epinephrine as a stimulus to the secretion of the acrosomal content, and K+ as a mediator of the stimulus signal. K+ influx through the cotransport mechanism occurs during capacitation, that this mechanism is activated late during the process, and that it probably mediates the stimulatory effects of epinephrine. Apparently, the activation of passive cation transport mechanisms is a general phenomenon in biological signal transduction.
dc.fuente.origenWOS
dc.identifier.issn0022-104X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99720
dc.identifier.wosidWOS:A1985ANB9400012
dc.issue.numero2
dc.language.isoen
dc.pagina.final267
dc.pagina.inicio261
dc.revistaJournal of experimental zoology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEPINEPHRINE DECREASES THE POTASSIUM REQUIREMENTS OF HAMSTER SPERM CAPACITATION - FUROSEMIDE BLOCKS THE EFFECT OF EPINEPHRINE
dc.typeartículo
dc.volumen235
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas