BENIGN FIBROUS HISTIOCYTOMA OF THE SKIN - AN IMMUNOHISTOCHEMICAL ANALYSIS OF 30 CASES

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dc.contributor.authorGONZALEZ, S
dc.date.accessioned2025-01-23T19:27:02Z
dc.date.available2025-01-23T19:27:02Z
dc.date.issued1985
dc.description.abstractIn this study the immunohistochemical analysis of distinct morphologic variants of benign fibrous histiocytoma (BFH) of the skin was performed with immunoperoxidase technique for both lysozyme and alpha-1-antitrypsin (A1AT). Thirty cases including cellular, fibrous and xanthomatous variants of BFH were selected. Out of the total 6 cases (20%) showed positive staining only for A1AT, 3 cases (10%) only for lysozyme and 10 (33.3%) for both markers. Thus, 19 cases (63.3%) showed positive staining for one of both markers. Positive staining was higher in the cellular variant than the fibrous and xanthomatous types. Negative staining of tumors of definite histiocytic morphology may be interpreted as a variable enzymatic expression of differet histiocytic activation and/or undetectable enzymatic content by the current techniques. These results are in accordance with our previous evolutional hypothesis of BFH which considered the cellular tumors as functionally more active variants evolving to less cellular, more fibrous and less active types. Current histogenetic concepts about this controversial group of skin neoplasms are discussed.
dc.fuente.origenWOS
dc.identifier.eissn1618-0631
dc.identifier.issn0344-0338
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99681
dc.identifier.wosidWOS:A1985AWA1500004
dc.issue.numero5
dc.language.isoen
dc.pagina.final489
dc.pagina.inicio486
dc.revistaPathology research and practice
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBENIGN FIBROUS HISTIOCYTOMA OF THE SKIN - AN IMMUNOHISTOCHEMICAL ANALYSIS OF 30 CASES
dc.typeartículo
dc.volumen180
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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