Emerging role of Metformin in Alzheimer's disease: A translational view

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dc.contributor.authorRios, Juvenal A.
dc.contributor.authorBorquez, Juan Carlos
dc.contributor.authorGodoy, Juan A.
dc.contributor.authorZolezzi, Juan M.
dc.contributor.authorFurrianca, Maria Cristina
dc.contributor.authorInestrosa, Nibaldo C.
dc.date.accessioned2025-01-20T16:11:01Z
dc.date.available2025-01-20T16:11:01Z
dc.date.issued2024
dc.description.abstractAlzheimer's disease (AD) constitutes a major public-health issue of our time. Regrettably, despite our considerable understanding of the pathophysiological aspects of this disease, current interventions lead to poor outcomes. Furthermore, experimentally promising compounds have continuously failed when translated to clinical trials. Along with increased population ageing, Type 2 Diabetes Mellitus (T2DM) has become an extremely common condition, mainly due to unbalanced dietary habits. Substantial epidemiological evidence correlates T2DM with cognitive impairment as well. Considering that brain insulin resistance, mitochondrial dysfunction, oxidative stress, and amyloidogenesis are common phenomena, further approaching the common features among these pathological conditions. Metformin constitutes the first-choice drug to preclude insulin resistance in T2DM clinical management. Experimental evidence suggests that its functions might include neuroprotective effects, in addition to its hypoglycemic activity. This review aims to summarize and discuss current knowledge of experimental data on metformin on this path towards translational medicine. Finally, we discuss the controversial data of responses to metformin in vitro, and in vivo, animal models and human studies.
dc.description.funderFaculty of Biological Sciences, Pontifical Catholic University of Chile
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.arr.2024.102439
dc.identifier.eissn1872-9649
dc.identifier.issn1568-1637
dc.identifier.urihttps://doi.org/10.1016/j.arr.2024.102439
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90244
dc.identifier.wosidWOS:001290092300001
dc.language.isoen
dc.revistaAgeing research reviews
dc.rightsacceso restringido
dc.subjectMetformin
dc.subjectAlzheimer<acute accent>s disease
dc.subjectType 2 diabetes mellitus
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEmerging role of Metformin in Alzheimer's disease: A translational view
dc.typeartículo
dc.volumen100
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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