EFFECT OF ENDOTHELIN ON TOTAL AND REGIONAL CORONARY RESISTANCE AND ON MYOCARDIAL-CONTRACTILITY

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dc.contributor.authorDOMENECH, R
dc.contributor.authorMACHO, P
dc.contributor.authorGONZALEZ, R
dc.contributor.authorHUIDOBROTORO, JP
dc.date.accessioned2025-01-23T19:22:48Z
dc.date.available2025-01-23T19:22:48Z
dc.date.issued1991
dc.description.abstractEndothelin is a 21-amino acid peptide produced by the endothelium and has a potent vasoconstrictor effect. Because of the importance of the endothelium on vasomotor regulation, we studied the effect of endothelin on total and regional coronary vascular resistance and on myocardial contractility in the intact heart of anesthetized dogs. Intracoronary administration of 2 to 80 pmol/kg of endothelin produced a dose-dependent increase in coronary resistance, ischaemic decrease in myocardial contractility and atrium-ventricular blockade. The increase in resistance was greater towards the outer layer of the left ventricular wall. When the coronaries were perfused at a constant rate and vasoconstriction was prevented with adenosine or nitroglycerine, endothelin did not produce inotropic changes. These results show that endothelin is a potent vasoconstrictor of the resistance coronary vessels, producing a redistribution of transmural blood flow and a decrease in myocardial contractility secondary to ischaemia.
dc.fuente.origenWOS
dc.identifier.issn0014-2999
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99105
dc.identifier.wosidWOS:A1991EX38800014
dc.issue.numero3
dc.language.isoen
dc.pagina.final416
dc.pagina.inicio409
dc.revistaEuropean journal of pharmacology
dc.rightsacceso restringido
dc.subjectENDOTHELINS
dc.subjectCORONARY CIRCULATION
dc.subjectTRANSMURAL FLOW
dc.subjectMYOCARDIAL ISCHEMIA
dc.subjectENDOTHELIUM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEFFECT OF ENDOTHELIN ON TOTAL AND REGIONAL CORONARY RESISTANCE AND ON MYOCARDIAL-CONTRACTILITY
dc.typeartículo
dc.volumen192
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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