RNA-Binding Proteins as Regulators of Internal Initiation of Viral mRNA Translation

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dc.contributor.authorLopez Ulloa, Brenda
dc.contributor.authorFuentes, Yazmin
dc.contributor.authorPizarro Ortega, Magdalena S.
dc.contributor.authorLopez Lastra, Marcelo
dc.date.accessioned2025-05-01T10:30:22Z
dc.date.available2025-05-01T10:30:22Z
dc.date.issued2022
dc.description.abstractViruses are obligate intracellular parasites that depend on the host's protein synthesis machinery for translating their mRNAs. The viral mRNA (vRNA) competes with the host mRNA to recruit the translational machinery, including ribosomes, tRNAs, and the limited eukaryotic translation initiation factor (eIFs) pool. Many viruses utilize non-canonical strategies such as targeting host eIFs and RNA elements known as internal ribosome entry sites (IRESs) to reprogram cellular gene expression, ensuring preferential translation of vRNAs. In this review, we discuss vRNA IRES-mediated translation initiation, highlighting the role of RNA-binding proteins (RBPs), other than the canonical translation initiation factors, in regulating their activity.
dc.description.funderAgencia Nacional de Investigacion y Desarrollo (ANID)
dc.description.funderGobierno de Chile
dc.description.funderPrograma Iniciativa Cientifica Milenio (ICM)
dc.description.funderIMII
dc.description.funderVicerrectoria de Investigacion (VRI)
dc.description.funderPontificia Universidad Catolica de Chile
dc.description.funderANID-Doctoral Fellowships
dc.format.extent38 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3390/v14020188
dc.identifier.eissn1999-4915
dc.identifier.issn2175-3369
dc.identifier.pubmedidMEDLINE:35215780
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:65649135122
dc.identifier.urihttps://doi.org/10.3390/v14020188
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103624
dc.identifier.wosidWOS:000762461600001
dc.information.autorucEscuela de Medicina; Lopez Lastra Marcelo Andres; 0000-0002-7936-8478; 84823
dc.information.autorucFacultad de Ciencias Biológicas; Pizarro Ortega Magdalena Sofia; S/I; 220989
dc.issue.numero2
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final16
dc.pagina.inicio4
dc.relation.ispartof16th International Vasculitis & ANCA Workshop
dc.revistaVIRUSES-BASEL
dc.rightsregistro bibliográfico
dc.subjectinternal ribosome entry site
dc.subjectIRES
dc.subjectRNA-binding protein
dc.subjectRBP
dc.subjectIRES-transacting factor
dc.subjectITAF
dc.subjectRIBOSOME-ENTRY SITE
dc.subjectHEPATITIS-C VIRUS
dc.subjectCAP-INDEPENDENT TRANSLATION
dc.subjectIRES-MEDIATED TRANSLATION
dc.subjectMOUTH-DISEASE VIRUS
dc.subjectCRICKET-PARALYSIS-VIRUS
dc.subject5 NONTRANSLATED REGION
dc.subjectTRANS-ACTING FACTORS
dc.subjectHETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS
dc.subjectCOLD-SHOCK DOMAINS
dc.subject.ddc400
dc.subject.deweyLenguases_ES
dc.subject.ods11 Sustainable cities and communities
dc.subject.odspa11 Ciudades y comunidades sostenibles
dc.titleRNA-Binding Proteins as Regulators of Internal Initiation of Viral mRNA Translation
dc.typeartículo
dc.volumen14
sipa.codpersvinculados84823
sipa.codpersvinculados220989
sipa.indexWOS
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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