CENTRAL EFFECTS OF MORPHINE, LEVORPHANOL, ( - )-METHADONE AND THE OPIOID-LIKE PEPTIDES BETA-ENDORPHIN AND D-ALANINE2-METHIONINE ENKEPHALINAMIDE ON URINE VOLUME OUTFLOW AND ELECTROLYTES

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dc.contributor.authorHUIDOBROTORO, JP
dc.contributor.authorHUIDOBRO, F
dc.date.accessioned2025-01-23T19:44:18Z
dc.date.available2025-01-23T19:44:18Z
dc.date.issued1981
dc.description.abstractThe intraventricular injection of 10-30 nmol of morphine, (-)-methadone or levorphanol caused a reduction in the volume of the urine output in rats previously hydrated with 0.5% NaCl. The decrease in urine outflow was associated with a dose-dependent reduction in the concentration of urine Na+ and K+. Two opioid-like peptides: .beta.-endorphin and D-alanine2 methionine enkephalinamide shared this morphine action. On a molar basis, .beta.-endorphin was about 100 times more potent than morphine to cause an equivalent antidiuresis. Naloxone injected i.p. antagonized the response of centrally administered morphine or .beta.-endorphin on urine formation and composition. (+)-Methadone or dextrorphan injected into the cerebral ventricles were considerably less active than their corresponding stereoisomers. N-methyl morphine injected i.p. was completely inactive up to doses that caused signs of toxicity; when injected into the lateral cerebral ventricles, it produced a decrease in the urine outflow and a reduction in the concentration of urine electrolytes. The pattern of changes in urine electrolytes produced by morphine and surrogates as well as the opioid-like peptides was in marked contrast to that caused by the i.p. administration of vasopressin. Whereas the i.p. administration of antidiuretic hormone caused oliguria and a large increase in the urine concentration of Na+ and K+, all the opiates produced at comparable antidiuresis a marked reduction in urine electrolytes. The opiates and the opioid-like peptides may selectively activate central opiate receptors to produce changes in urine formation and composition. Results are discussed in relation to probable central opiate mechanisms controlling the production and formation of urine.
dc.fuente.origenWOS
dc.identifier.eissn1521-0103
dc.identifier.issn0022-3565
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100001
dc.identifier.wosidWOS:A1981LU32000008
dc.issue.numero3
dc.language.isoen
dc.pagina.final585
dc.pagina.inicio579
dc.revistaJournal of pharmacology and experimental therapeutics
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCENTRAL EFFECTS OF MORPHINE, LEVORPHANOL, ( - )-METHADONE AND THE OPIOID-LIKE PEPTIDES BETA-ENDORPHIN AND D-ALANINE2-METHIONINE ENKEPHALINAMIDE ON URINE VOLUME OUTFLOW AND ELECTROLYTES
dc.typeartículo
dc.volumen217
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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