Nasal natural killer/T-cell lymphoma and its association with type "i"/Xhol loss strain Epstein-Barr virus in Chile

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dc.contributor.authorCabrera, M. E.
dc.contributor.authorEizuru, Y.
dc.contributor.authorItoh, T.
dc.contributor.authorKoriyama, C.
dc.contributor.authorTashiro, Y.
dc.contributor.authorDing, S.
dc.contributor.authorRey, S.
dc.contributor.authorAkiba, S.
dc.contributor.authorCorvalan, A.
dc.date.accessioned2024-01-10T12:40:45Z
dc.date.available2024-01-10T12:40:45Z
dc.date.issued2007
dc.description.abstractBackground: Nasal T/natural killer (NK)-cell lymphoma is an aggressive type of non-Hodking's lymphoma associated with Epstein-Barr virus (EBV) and striking geographical variations worldwide.
dc.description.abstractAim: To characterise nasal NK/T-cell lymphoma associated with genotypes of EBV in Chile, a Latin American country, where multiple strains of EBV, including two new recombinant strains, in healthy individuals were recently found.
dc.description.abstractMethods: Cases with diagnosis of primary nasal lymphoma were selected for histological and immunohistochemical analysis (CD3, CD3e, CD4, CD8, CD79a, CD56, CD57 and TIA-1) and in-situ hybridisation, serology and genotyping analysis for EBV.
dc.description.abstractResults: Out of 22 cases, 9 (41%) cases fulfilled the World Health Organization criteria for nasal NK/T-cell lymphoma; of these 7 (78%) cases were positive for EBV. Genotyping analysis revealed 6 cases of type 1 EBV and wildtype F at the BamHI-F region, 4 cases type "i" EBV at the BamHI-W1/I1 region; XhoI wild type was found in 2 and XhoI loss in 4 cases, respectively. Cosegregation analysis of the BamHI-W1/I1 region and XhoI restriction site showed the new recombinant strain type "i"/Xhol loss in 3 cases and type "i"/Xhol wildtype strain in 1 case. Most patients were treated with combined anthracycline-containing regimens. Half of the cases attained complete remission.
dc.description.abstractConclusion: Although nasal NK/T-cell lymphomas from Chile share similar clinicopathological features, high association with EBV and unfavourable prognosis with those described elsewhere, genotype analysis shows that the new recombinant type "i"/Xhol loss strain might contribute to explain the intermediate incidence of nasal NK/T-cell lymphomas in Latin America.
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1136/jcp.2005.034199
dc.identifier.issn0021-9746
dc.identifier.pubmedidMEDLINE:16775124
dc.identifier.urihttps://doi.org/10.1136/jcp.2005.034199
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77344
dc.identifier.wosidWOS:000247125300014
dc.information.autorucMedicina;Corvalan A;S/I;63885
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final660
dc.pagina.inicio656
dc.publisherB M J PUBLISHING GROUP
dc.revistaJOURNAL OF CLINICAL PATHOLOGY
dc.rightsacceso restringido
dc.subjectNON-HODGKINS-LYMPHOMAS
dc.subjectT-CELL
dc.subjectNASOPHARYNGEAL CARCINOMA
dc.subjectSOUTHERN CHINA
dc.subjectT/NK LYMPHOMAS
dc.subjectUNITED-STATES
dc.subjectHONG-KONG
dc.subjectGENE
dc.subjectEBV
dc.subjectEPIDEMIOLOGY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNasal natural killer/T-cell lymphoma and its association with type "i"/Xhol loss strain Epstein-Barr virus in Chile
dc.typeartículo
dc.volumen60
sipa.codpersvinculados63885
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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