ULTRASTRUCTURAL MYOCARDIAL PRESERVATION DURING CORONARY-ARTERY SURGERY - A CONTROLLED, PROSPECTIVE, RANDOMIZED STUDY IN HUMANS

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dc.contributor.authorMORAN, SV
dc.contributor.authorCHUAQUI, B
dc.contributor.authorIRARRAZAVAL, MJ
dc.contributor.authorTHOMSEN, P
dc.contributor.authorNAVARRO, M
dc.contributor.authorURZUA, J
dc.contributor.authorMATURANA, G
dc.date.accessioned2025-01-23T19:26:50Z
dc.date.available2025-01-23T19:26:50Z
dc.date.issued1986
dc.description.abstractPotassium cardioplegia was compared with normothermic, intermittent ischemic arrest in 30 patients undergoing multiple coronary artery bypass grafts. Group 1 comprised 15 patients in whom cold potassium cardioplegia with St. Thomas'' Hospital solution was used. In Group 2 were 15 patients who underwent intermittent ischemic arrest during the construction of the distal anastomoses. Two myocardial transmural left ventricular biopsies were done in each patient. There was no operative mortality. Electron microscopical examination showed normal myocardial ultrastructure in both groups. In particular, mitochondria were well preserved in all samples. The postoperative electrocardiogram demonstrated a new Q wave in 1 patient in Group 2 whose level of the myocardial isoenzyme of creatine phosphokinase (CPK-MB) was within the normal range. The peak CPK-MB release in Group 1 was 23.2 .+-. 20.1 IU and in Group 2, 19.9 .+-. 15.1 IU. This difference was not statistically significant. The mean period of anoxic arrest in Group 1 was 49.5 .+-. 15 minutes and in Group 2, 25.5 .+-. 8 minutes (p < 0.001). Total cardiopulmonary bypass time in Group 1 was 114.5 .+-. 20 minutes and in Group 2, 90.2 .+-. 16 minutes (p < 0.01). It is concluded that both techniques can preserve myocardial subcellular architecture during multiple coronary artery bypass grafting in patients with normal left ventricular function.
dc.fuente.origenWOS
dc.identifier.eissn1552-6259
dc.identifier.issn0003-4975
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99658
dc.identifier.wosidWOS:A1986AXR3000014
dc.issue.numero1
dc.language.isoen
dc.pagina.final84
dc.pagina.inicio79
dc.revistaAnnals of thoracic surgery
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleULTRASTRUCTURAL MYOCARDIAL PRESERVATION DURING CORONARY-ARTERY SURGERY - A CONTROLLED, PROSPECTIVE, RANDOMIZED STUDY IN HUMANS
dc.typeartículo
dc.volumen41
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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