The role of mesenchymal stem cells in early programming of adipose tissue in the offspring of women with obesity

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dc.article.numbere13120
dc.catalogadorgjm
dc.contributor.authorBellalta Bremer, Sofía Paz
dc.contributor.authorPlösch, Torsten
dc.contributor.authorFaas, Marijke
dc.contributor.authorCasanello Toledo, Paola Cecilia
dc.date.accessioned2024-04-17T14:15:28Z
dc.date.available2024-04-17T14:15:28Z
dc.date.issued2024
dc.description.abstractMaternal obesity is a well-known risk factor for developing premature obesity, metabolic syndrome, cardiovascular disease and type 2 diabetes in the progeny. The development of white adipose tissue is a dynamic process that starts during prenatal life: fat depots laid down in utero are associated with the proportion of fat in children later on. How early this programming takes place is still unknown. However, recent evidence shows that mesenchymal stem cells (MSC), the embryonic adipocyte precursor cells, show signatures of the early setting of an adipogenic committed phenotype when exposed to maternal obesity. This review aims to present current findings on the cellular adaptations of MSCs from the offspring of women with obesity and how the metabolic environment of MSCs could affect the early commitment towards adipocytes. In conclusion, maternal obesity can induce early programming of fetal adipose tissue by conditioning MSCs. These cells have higher expression of adipogenic markers, altered insulin signalling and mitochondrial performance, compared to MSCs of neonates from lean pregnancies. Fetal MSCs imprinting by maternal obesity could help explain the increased risk of childhood obesity and development of further noncommunicable diseases.
dc.fechaingreso.objetodigital2024-04-17
dc.format.extent9 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1111/ijpo.13120
dc.identifier.eissn2047-6310
dc.identifier.issn2047-6302
dc.identifier.urihttps://doi.org/10.1111/ijpo.13120
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/85154
dc.identifier.wosidWOS:001198498600001
dc.information.autorucEscuela de Medicina; Bellalta Bremer, Sofía Paz; 0009-0000-8743-3172; 1092183
dc.information.autorucEscuela de Medicina; Casanello Toledo, Paola Cecilia; 0000-0002-2355-1476; 146772
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaPediatric Obesity
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdipogenesis
dc.subjectAdipose tissue
dc.subjectFetal programming
dc.subjectMesenchymal stem cells
dc.subjectObesity
dc.subjectPregnancy
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe role of mesenchymal stem cells in early programming of adipose tissue in the offspring of women with obesity
dc.typepreprint
sipa.codpersvinculados1092183
sipa.codpersvinculados146772
sipa.trazabilidadORCID;2024-04-15
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