Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies

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dc.catalogadorjlo
dc.contributor.authorVilla, Sara
dc.contributor.authorAasvang, Eske K.
dc.contributor.authorAttal, Nadine
dc.contributor.authorBaron, Ralf
dc.contributor.authorBourinet, Emmanuel
dc.contributor.authorCalvo Bascuñán, Margarita
dc.contributor.authorFinnerup, Nanna B.
dc.contributor.authorGalosi, Eleonora
dc.contributor.authorHockley, James R. F.
dc.contributor.authorKarlsson, Pall
dc.contributor.authorKemp, Harriet
dc.contributor.authorKoerner, Jannis
dc.contributor.authorKutafina, Ekaterina
dc.contributor.authorLampert, Angelika
dc.contributor.authorMurk, Margarita
dc.contributor.authorNochi, Zahra
dc.contributor.authorPrice, Theodore J.
dc.contributor.authorRice, Andrew S. C.
dc.contributor.authorSommer, Claudia
dc.contributor.authorTaba, Pille
dc.date.accessioned2025-07-09T15:11:50Z
dc.date.available2025-07-09T15:11:50Z
dc.date.issued2025
dc.description.abstractNeuropathic pain remains difficult to treat, with drug development hampered by an incomplete understanding of the pathogenesis of the condition, as well as a lack of biomarkers. The problem is compounded by the scarcity of relevant human peripheral tissues, including skin, nerves, and dorsal root ganglia. Efforts to obtain such samples are accelerating, increasing the need for standardisation across laboratories. In this white paper, we report on a consensus meeting attended by neuropathic pain experts, designed to accelerate protocol alignment and harmonization of studies involving relevant peripheral tissues. The meeting was held in London in March 2024 and attended by 28 networking partners, including industry and patient representatives. We achieved consensus on minimal recommended phenotyping, harmonised wet laboratory protocols, statistical design, reporting, and data sharing. Here, we also share a variety of relevant standard operating procedures as supplementary protocols. We envision that our recommendations will help unify human tissue research in the field and accelerate our understanding of how abnormal interactions between sensory neurons and their local peripheral environment contribute towards neuropathic pain.
dc.fechaingreso.objetodigital2025-07-09
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/j.pain.0000000000003445
dc.identifier.eissn1872-6623
dc.identifier.issn0304-3959
dc.identifier.urihttps://doi.org/10.1097/j.pain.0000000000003445
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104886
dc.identifier.wosidWOS:001468499600001
dc.information.autorucEscuela de Medicina; Calvo Bascuñán, Margarita; 0000-0003-3349-9189; 3457
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final1001
dc.pagina.inicio994
dc.revistaPAIN
dc.rightsacceso abierto
dc.subjectNeuropathic pain
dc.subjectPeripheral nerve
dc.subjectDorsal root ganglia
dc.subjectProtocol harmonization
dc.subjectInflammation
dc.subjectNeuro-immune
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleHarmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies
dc.typereseña
dc.volumen166
sipa.codpersvinculados3457
sipa.trazabilidadWOS;2025-05-03
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