The matricellular protein thrombospondin-1 in lung inflammation and injury

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dc.catalogadoraba
dc.contributor.authorTabary, Mohammadreza
dc.contributor.authorGheware, Atish
dc.contributor.authorPeñaloza Cerda, Hernán F.
dc.contributor.authorLee, Janet S.
dc.date.accessioned2025-04-08T16:15:17Z
dc.date.available2025-04-08T16:15:17Z
dc.date.issued2022
dc.description.abstractMatricellular proteins comprise a diverse group of molecular entities secreted into the extracellular space. They interact with the extracellular matrix (ECM), integrins, and other cell-surface receptors, and can alter matrix strength, cell attachment to the matrix, and cell-cell adhesion. A founding member of this group is thrombospondin-1 (TSP-1), a high molecular-mass homotrimeric glycoprotein. Given the importance of the matrix and ECM remodeling in the lung following injury, TSP-1 has been implicated in a number of lung pathologies. This review examines the role of TSP-1 as a damage controller in the context of lung inflammation, injury resolution, and repair in noninfectious and infectious models. This review also discusses the potential role of TSP-1 in human diseases as it relates to lung inflammation and injury.
dc.description.funderNational Institutes of Health; Folios: R01 HL136143, P01HL114453, R01 HL142084, K24HL143285
dc.description.funderMillennium Science Initiative Program:Millennium Institute on Immunology and Immunotherapy; Folio: ICN09_016, ICN 2021_045; anterior P09/016-F
dc.format.extent9 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1152/ajpcell.00182.2022
dc.identifier.eissn1522-21563
dc.identifier.issn1522-1563
dc.identifier.pubmedid35912991
dc.identifier.scopusidSCOPUS_ID:85138126155
dc.identifier.urihttps://doi.org/10.1152/ajpcell.00182.2022
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103158
dc.identifier.wosidWOS:000892873800001
dc.information.autorucFacultad de Ciencias Biológicas; Peñaloza Cerda, Hernán F.; S/I; 186994
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.finalC865
dc.pagina.inicioC857
dc.revistaAmerican Journal of Physiology - Cell Physiology
dc.rightsacceso restringido
dc.subjectLung inflammation
dc.subjectLung injury
dc.subjectMatricellular protein
dc.subjectThrombospondin-1
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe matricellular protein thrombospondin-1 in lung inflammation and injury
dc.typereseña
dc.volumen323
sipa.codpersvinculados186994
sipa.trazabilidadORCID;2025-03-24
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