Diagnóstico precoz de la enfermedad de Parkinson

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dc.catalogadoryvc
dc.contributor.authorJuri Clavería, Carlos Andrés
dc.contributor.authorUribe San Martin, Reinaldo Moisés
dc.date.accessioned2025-06-18T23:13:26Z
dc.date.available2025-06-18T23:13:26Z
dc.date.issued2009
dc.description.abstractParkinson's disease (PD) is a neurodegenerative disorder clinically characterised by motor symptoms, and these manifestations arise after an extensive loss of dopaminergic neurons in the substantia nigra. In the last decades evidence has emerged to show that the onset of neurodegeneration in PD probably begins many years before the onset of motor symptoms. Additionally nonmotor manifestations, such as olfactory dysfunction, REM behavioural disorder, depression and constipation, also arise earlier than motor manifestations in the course of the disease. Neuroimages are useful in identifying subjects at risk of developing PD, as the result of early non-motor manifestations, or carriers of genetic mutations associated with familial PD. In this article we review the available evidence in diagnosing PD in the early non-motor stage and how this approach could help us to improve the treatment of PD patients
dc.description.abstractEn este artículo revisamos la información disponible sobre el diagnóstico en la etapa temprana de la enfermedad de Parkinson, antes de los síntomas motores y cómo esta estrategia puede ser de utilidad en el mejor tratamiento de esta población de pacientes.
dc.fuente.origenScopus
dc.identifier.issn1667-8982
dc.identifier.scopusidScopus_ID: 60749106279
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104692
dc.identifier.wosidWoS_ID: 000207880600002
dc.information.autorucEscuela de Medicina; Juri Clavería, Carlos Andrés; 0000-0002-1939-5976; 7476
dc.information.autorucEscuela de Medicina; Uribe San Martin, Reinaldo Moisés; 0000-0002-3422-7962; 127201
dc.issue.numero8
dc.language.isoes
dc.nota.accesocontenido parcial
dc.pagina.final844
dc.pagina.inicio839
dc.publisherSociedad Iberoamericana de Información Científica (SIIC),
dc.revistaSalud (i) Ciencia
dc.rightsacceso restringido
dc.subjectEarly diagnosis
dc.subjectFunctional neuroimagen
dc.subjectOlfactory dysfunction
dc.subjectParkinson's disease
dc.subjectREM behavioural disorder
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDiagnóstico precoz de la enfermedad de Parkinson
dc.title.alternativeEarly diagnosis of Parkinson's disease
dc.typeartículo de revisión
dc.volumen16
sipa.codpersvinculados7476
sipa.codpersvinculados127201
sipa.trazabilidadScopus;12-10-2021
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