L-GLUTAMIC ACID, A NEUROMODULATOR OF DOPAMINERGIC TRANSMISSION IN THE RAT CORPUS STRIATUM

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dc.contributor.authorRUDOLPH, MI
dc.contributor.authorARQUEROS, L
dc.contributor.authorBUSTOS, G
dc.date.accessioned2025-01-23T19:43:53Z
dc.date.available2025-01-23T19:43:53Z
dc.date.issued1983
dc.description.abstractA superfusion system was used to study the effects of neuroexcitatory amino acids upon spontaneous and depolarization-evoked release of exogenously taken up and newly synthesized [3H]dopamine by rat striatal slices. Neither L-glutamate nor other aminoacids such as L-aspartate and D-glutamate (5 .times. 10-5 M) modified the spontaneous release of exogenous [3H]dopamine from rat striatal slices. These neuroexcitatory aminoacids did potentiate spontaneous release of striatal [3H]dopamine newly synthesized from [3H]tyrosine. A different pattern of effects emerged when depolarization-evoked release of dopamine was studied. Only L-glutamate (5 .times. 10-6-1 .times. 10-4 M) potentiated dopamine release under these experimental conditions in a rather specific and stereoselective manner. Similar results were obtained regardless of whether depolarization-induced release of exogenous or newly synthesized [3H]dopamine was studied. The effect of L-glutamate on depolarization-induced release depended both upon the degree of neuronal depolarization and upon the presence of external Ca2+ in the superfusion medium and it was blocked by L-glutamate diethylester. This effect of L-glutamate seemed quite specific with regard to regional localization within the brain as it was only demonstrated in slices from striatum and not in slices from olfactory tubercle or hippocampus. It is suggested that during depolarization a Ca2+-dependent event occurs at the striatal membrane level which changes the sensitivity of the dopamine release process to neuroexcitatory aminoacids in such a way as to render it relatively more specific and steroselective towards L-glutamate stimulation. Evidently L-glutamic acid could play a role as a neuromodulator of dopaminergic transmission in the rat corpus striatum.
dc.fuente.origenWOS
dc.identifier.eissn1872-9754
dc.identifier.issn0197-0186
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99858
dc.identifier.wosidWOS:A1983RH68700017
dc.issue.numero4
dc.language.isoen
dc.pagina.final486
dc.pagina.inicio479
dc.revistaNeurochemistry international
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleL-GLUTAMIC ACID, A NEUROMODULATOR OF DOPAMINERGIC TRANSMISSION IN THE RAT CORPUS STRIATUM
dc.typeartículo
dc.volumen5
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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