Neuropeptide Y Y-1 receptors are involved in the vasoconstriction caused by human sympathetic nerve stimulation

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dc.contributor.authorRacchi, H
dc.contributor.authorSchliem, AJ
dc.contributor.authorDonoso, MV
dc.contributor.authorRahmer, A
dc.contributor.authorZuniga, A
dc.contributor.authorGuzman, S
dc.contributor.authorRudolf, K
dc.contributor.authorHuidobroToro, JP
dc.date.accessioned2025-01-21T01:33:16Z
dc.date.available2025-01-21T01:33:16Z
dc.date.issued1997
dc.description.abstractNeuropeptide Y, a novel neurotransmitter, interacts with selective membrane receptors to cause vasoconstriction. Frequency- and concentration-dependent isometric contractions were observed in human inferior mesenteric artery and vein mounted rings that were stimulated with either electrical pulses (70 V, 0.5 ms, 2.5-20 Hz) or noradrenaline. The antagonism elicited by 100 nM tetrodotoxin and 1 mu M guanethidine confirmed the neuronal and sympathetic origins of the vasomotor response. Incubation with BIBP 3226 ((R)-N-2-(diphrnacetyl)-N-(4-hydroxyphenyl)-methyl-D-arginineamide), a selective neuropeptide Y Y, receptor antagonist, significantly reduced the vasoconstriction. The incomplete antagonist activity of BIBP 3226 tends to support the hypothesis of sympathetic co-transmission involving neuropeptide Y, adenosine 5'-triphosphate and noradrenaline. These findings were confirmed in parallel studies using rat superior mesenteric artery and vein ring preparations. (C) 1997 Elsevier Science B.V.
dc.fuente.origenWOS
dc.identifier.issn0014-2999
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97396
dc.identifier.wosidWOS:A1997XG82800011
dc.issue.numero1
dc.language.isoen
dc.pagina.final83
dc.pagina.inicio79
dc.revistaEuropean journal of pharmacology
dc.rightsacceso restringido
dc.subjectBIBP 3226
dc.subjectneuropeptide Y receptor
dc.subjectneuropeptide Y Y-1 receptor
dc.subjectsympathetic stimulation
dc.subjectmesenteric artery, human, inferior
dc.subjectmesenteric vein, human, inferior
dc.subject.ods02 Zero Hunger
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa02 Hambre cero
dc.subject.odspa03 Salud y bienestar
dc.titleNeuropeptide Y Y-1 receptors are involved in the vasoconstriction caused by human sympathetic nerve stimulation
dc.typeartículo
dc.volumen329
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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