Post-COVID-19 condition: a sex-based analysis of clinical and laboratory trends

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dc.contributor.authorDelfino, Carlos
dc.contributor.authorPoli, M. Cecilia
dc.contributor.authorVial, Cecilia
dc.contributor.authorVial, Pablo A.
dc.contributor.authorMartinez, Gonzalo
dc.contributor.authorRiviotta, Amy
dc.contributor.authorArbat, Catalina
dc.contributor.authorMac-Guire, Nicole
dc.contributor.authorHoppe, Josefina
dc.contributor.authorCarvajal, Cristobal
dc.contributor.authorVenturelli, Paula Munoz
dc.date.accessioned2025-01-20T16:14:53Z
dc.date.available2025-01-20T16:14:53Z
dc.date.issued2024
dc.description.abstractBackground and aim Post-COVID-19 condition (PCC) encompasses long-lasting symptoms in individuals with COVID-19 and is estimated to affect between 31-67% of patients, with women being more commonly affected. No definitive biomarkers have emerged in the acute stage that can help predict the onset of PCC, therefore we aimed at describing sex-disaggregated data of PCC patients from a local cohort and explore potential acute predictors of PCC and neurologic PCC. Methods A local cohort of consecutive patients admitted with COVID-19 diagnosis between June 2020 and July 2021 were registered, and clinical and laboratory data were recorded. Only those <65 years, discharged alive and followed up at 6 and 12 months after admission were considered in these analyses. Multivariable logistic regression analysis was performed to explore variables associated with PCC (STATA v 18.0). Results From 130 patients in the cohort, 104 were contacted: 30% were women, median age of 42 years. At 6 months, 71 (68%) reported PCC symptoms. Women exhibited a higher prevalence of any PCC symptom (87 vs. 60%, p = 0.007), lower ferritin (p = 0.001) and procalcitonin (p = 0.021) and higher TNF levels (p = 0.042) in the acute phase compared to men. Being women was independently associated to 7.60 (95% CI 1.27-45.18, p = 0.026) higher risk for PCC. Moreover, women had lower return to normal activities 6 and 12 months. Conclusion Our findings highlight the lasting impact of COVID-19, particularly in young women, emphasising the need for tailored post-COVID care. The lower ferritin levels in women are an intriguing observation, warranting further research. The study argues for comprehensive strategies that address sex-specific challenges in recovery from COVID-19.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fmed.2024.1376030
dc.identifier.eissn2296-858X
dc.identifier.urihttps://doi.org/10.3389/fmed.2024.1376030
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90465
dc.identifier.wosidWOS:001253478300001
dc.language.isoen
dc.revistaFrontiers in medicine
dc.rightsacceso restringido
dc.subjectpost COVID-19 condition
dc.subjectlong COVID
dc.subjectCOVID-19
dc.subjectsex-disaggregated
dc.subjectneurologic long-COVID-19
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePost-COVID-19 condition: a sex-based analysis of clinical and laboratory trends
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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