Severe menopausal symptoms linked to cognitive impairment: an exploratory study

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dc.contributor.authorCalle, Andres
dc.contributor.authorBlumel, Juan E.
dc.contributor.authorChedraui, Peter
dc.contributor.authorVallejo, Maria S.
dc.contributor.authorBelardo, Alejandra
dc.contributor.authorDextre, Maribel
dc.contributor.authorElizalde-Cremonte, Alejandra
dc.contributor.authorEscalante, Carlos
dc.contributor.authorEspinoza, Maria T.
dc.contributor.authorGomez-Tabares, Gustavo
dc.contributor.authorMonterrosa-Castro, Alvaro
dc.contributor.authorNanez, Monica
dc.contributor.authorOjeda, Eliana
dc.contributor.authorRey, Claudia
dc.contributor.authorRodriguez, Doris
dc.contributor.authorRodrigues, Marcio A.
dc.contributor.authorSalinas, Carlos
dc.contributor.authorTserotas, Konstantinos
dc.contributor.authorAedo, Socrates
dc.date.accessioned2025-01-20T16:04:56Z
dc.date.available2025-01-20T16:04:56Z
dc.date.issued2024
dc.description.abstractObjective: To evaluate the association between menopausal symptoms and cognitive decline in postmenopausal women. Methods: This was a subanalysis of a cross-sectional, observational study conducted among women attending gynecological consultations across nine Latin American countries. The survey involved late postmenopausal women who were asked to complete a general questionnaire and the Menopause Rating Scale (MRS) to assess menopausal symptoms, with the Montreal Cognitive Assessment used to evaluate cognitive function as an outcome. A Montreal Cognitive Assessment score of less than 21 was used to define women with mild cognitive impairment (MCI). Results: The study included 1,287 postmenopausal women with a mean age of 55.5 years and a mean body mass index of 26.3 kg/m2. On average, participants had 13.8 years of education and 2.3 +/- 1.8 children, with 72.8% reporting having a partner. Additionally, 36.7% ever used menopausal hormone therapy. Regarding lifestyle factors, 50.3% engaged in a sedentary lifestyle, whereas 70.5% had never smoked. 15.3% of women had MCI exhibited significantly more intense menopausal symptoms compared with those without MCI (MRS total score 15.24 +/- 12.58 vs 10.53 +/- 8.84, respectively, P < 0.001). Logistic regression analysis revealed a significant association between severe menopausal symptoms (MRS total score >= 14 points) and MCI (odds ratio [OR], 1.74; 95% CI, 1.25-2.42). Conversely, a lower body mass index (OR, 0.96; 95% CI, 0.95-0.98), sexual activity (OR, 0.70; 95% CI, 0.51-0.96), physical exercise (OR, 0.55; 95% CI, 0.39-0.76), menopausal hormone therapy use (OR, 0.36; 95% CI, 0.24-0.55), and higher educational level (OR, 0.31; 95% CI, 0.21-0.46) were associated with lower odds for MCI. Conclusion: Severe menopausal symptoms in postmenopausal women were associated with cognitive impairment. This study highlights the intricate interplay between hormonal, lifestyle, and sociodemographic factors and cognitive health.
dc.fuente.origenWOS
dc.identifier.doi10.1097/GME.0000000000002422
dc.identifier.eissn1530-0374
dc.identifier.issn1072-3714
dc.identifier.urihttps://doi.org/10.1097/GME.0000000000002422
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89856
dc.identifier.wosidWOS:001343724500006
dc.issue.numero11
dc.language.isoen
dc.pagina.final965
dc.pagina.inicio959
dc.revistaMenopause-the journal of the menopause society
dc.rightsacceso restringido
dc.subjectMenopausal hormone therapy
dc.subjectMenopausal symptoms
dc.subjectMenopause Rating Scale
dc.subjectMild cognitive impairment
dc.subjectMontreal Cognitive Assessment
dc.titleSevere menopausal symptoms linked to cognitive impairment: an exploratory study
dc.typeartículo
dc.volumen31
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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