Free-breathing, Contrast Agent-free Whole-Heart MTC-BOOST Imaging: Single-Center Validation Study in Adult Congenital Heart Disease

Simple item page
dc.contributor.authorFotaki, Anastasia
dc.contributor.authorPushparajah, Kuberan
dc.contributor.authorHajhosseiny, Reza
dc.contributor.authorSchneider, Alina
dc.contributor.authorAlam, Harith
dc.contributor.authorFerreira, Joana
dc.contributor.authorNeji, Radhouene
dc.contributor.authorKunze, Karl P.
dc.contributor.authorFrigiola, Alessandra
dc.contributor.authorBotnar, Rene M.
dc.contributor.authorPrieto, Claudia
dc.date.accessioned2025-01-20T20:16:35Z
dc.date.available2025-01-20T20:16:35Z
dc.date.issued2023
dc.description.abstractPurpose: To assess the clinical performance of the three-dimensional, free-breathing, Magnetization Transfer Contrast Bright-and-black blOOd phase-SensiTive (MTC-BOOST) sequence in adult congenital heart disease (ACHD).Materials and Methods: In this prospective study, participants with ACHD undergoing cardiac MRI between July 2020 and March 2021 were scanned with the clinical T2-prepared balanced steady-state free precession sequence and proposed MTC-BOOST sequence. Four cardiologists scored their diagnostic confidence on a four-point Likert scale for sequential segmental analysis on images acquired with each sequence. Scan times and diagnostic confidence were compared using the Mann-Whitney test. Coaxial vascular dimensions at three anatomic landmarks were measured, and agreement between the research sequence and the corresponding clinical sequence was assessed with Bland-Altman analysis.Results: The study included 120 participants (mean age, 33 years +/- 13 [SD]; 65 men). The mean acquisition time of the MTC-BOOST sequence was significantly lower compared with that of the conventional clinical sequence (9 minutes +/- 2 vs 14 minutes +/- 5; P < .001). Diagnostic confidence was higher for the MTC-BOOST sequence compared with the clinical sequence (mean, 3.9 +/- 0.3 vs 3.4 +/- 0.7; P < .001). Narrow limits of agreement and mean bias less than 0.08 cm were found between the research and clinical vascu-lar measurements.Conclusion: The MTC-BOOST sequence provided efficient, high-quality, and contrast agent-free three-dimensional whole-heart imag-ing in ACHD, with shorter, more predictable acquisition time and improved diagnostic confidence compared with the reference stan-dard clinical sequence.
dc.fuente.origenWOS
dc.identifier.doi10.1148/ryct.220146
dc.identifier.issn2638-6135
dc.identifier.urihttps://doi.org/10.1148/ryct.220146
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92340
dc.identifier.wosidWOS:000947148600011
dc.issue.numero1
dc.language.isoen
dc.revistaRadiology-cardiothoracic imaging
dc.rightsacceso restringido
dc.subjectMR Angiography
dc.subjectCardiac
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFree-breathing, Contrast Agent-free Whole-Heart MTC-BOOST Imaging: Single-Center Validation Study in Adult Congenital Heart Disease
dc.typeartículo
dc.volumen5
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas