Cross-species and mammal-to-mammal transmission of clade 2.3.4.4b highly pathogenic avian influenza A/H5N1 with PB2 adaptations

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dc.article.number2232
dc.catalogadorgjm
dc.contributor.authorPardo Roa, Catalina
dc.contributor.authorNelson, Martha I.
dc.contributor.authorAriyama, Naomi
dc.contributor.authorAguayo, Carolina
dc.contributor.authorAlmonacid Cárdenas, Leonardo Iván
dc.contributor.authorGonzalez-Reiche, Ana S.
dc.contributor.authorMuñoz, Gabriela
dc.contributor.authorUlloa, Mauricio
dc.contributor.authorAvila, Claudia
dc.contributor.authorNavarro, Carlos
dc.contributor.authorReyes, Rodolfo
dc.contributor.authorCastillo Torres, Pablo Nicolás
dc.contributor.authorMathieu, Christian
dc.contributor.authorVergara, Ricardo
dc.contributor.authorGonzalez, Alvaro
dc.contributor.authorGonzalez, Carmen Gloria
dc.contributor.authorAraya, Hugo
dc.contributor.authorCastillo, Andres
dc.contributor.authorTorres, Juan Carlos
dc.contributor.authorCovarrubias, Paulo
dc.contributor.authorBustos, Patricia
dc.contributor.authorvan Bakel, Harm
dc.contributor.authorFernandez, Jorge
dc.contributor.authorFasce, Rodrigo A.
dc.contributor.authorJohow, Magdalena
dc.contributor.authorNeira, Victor
dc.contributor.authorMedina, Rafael
dc.date.accessioned2025-06-26T19:31:24Z
dc.date.available2025-06-26T19:31:24Z
dc.date.issued2025
dc.description.abstractHighly pathogenic H5N1 avian influenza viruses (HPAIV) belonging to lineage 2.3.4.4b emerged in Chile in December 2022, leading to mass mortality events in wild birds, poultry, and marine mammals and one human case. We detected HPAIV in 7,33% (714/9745) of cases between December 2022-April 2023 and sequenced 177 H5N1 virus genomes from poultry, marine mammals, a human, and wild birds spanning >3800 km of Chilean coastline. Chilean viruses were closely related to Peru's H5N1 outbreak, consistent with north-to-south spread down the Pacific coastline. One human virus and nine marine mammal viruses in Chile had the rare PB2 D701N mammalian-adaptation mutation and clustered phylogenetically despite being sampled 5 weeks and hundreds of kilometers apart. These viruses shared additional genetic signatures, including another mammalian PB2 adaptation (Q591K, n = 6), synonymous mutations, and minor variants. Several mutations were detected months later in sealions in the Atlantic coast, indicating that the pinniped outbreaks on the west and east coasts of South America are genetically linked. These data support sustained mammal-to-mammal transmission of HPAIV in marine mammals over thousands of kilometers of Chile's Pacific coastline, which subsequently continued through the Atlantic coastline.
dc.fechaingreso.objetodigital2025-06-26
dc.format.extent15 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41467-025-57338-z
dc.identifier.eissn2041-1723
dc.identifier.urihttps://doi.org/10.1038/s41467-025-57338-z
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104768
dc.identifier.wosidWOS:001439685300006
dc.information.autorucFacultad de Ciencias Biológicas; Pardo Roa, Catalina; 0000-0002-5409-225X; 225251
dc.information.autorucFacultad de Ciencias Biológicas; Almonacid Cárdenas, Leonardo Iván; S/I; 250112
dc.information.autorucFacultad de Ciencias Biológicas; Castillo Torres, Pablo Nicolás; S/I; 1091352
dc.information.autorucEscuela de Medicina; Medina, Rafael; 0000-0002-5013-6884; 1000649
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaNature Communications
dc.rightsacceso abierto
dc.rights.licenseCC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.ods14 Life below water
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa14 Vida submarina
dc.titleCross-species and mammal-to-mammal transmission of clade 2.3.4.4b highly pathogenic avian influenza A/H5N1 with PB2 adaptations
dc.typeartículo
dc.volumen16
sipa.codpersvinculados225251
sipa.codpersvinculados250112
sipa.codpersvinculados1091352
sipa.codpersvinculados1000649
sipa.trazabilidadWOS;2025-03-15
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