Tetrahydrohyperforin Increases Adult Hippocampal Neurogenesis in Wild-Type and APPswe/PS1 ΔE9 Mice

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dc.contributor.authorAbbott, Ana C.
dc.contributor.authorToledo, Carla Calderon
dc.contributor.authorAranguiz, Florencia C.
dc.contributor.authorInestrosa, Nibaldo C.
dc.contributor.authorVarela-Nallar, Lorena
dc.date.accessioned2025-01-24T00:04:12Z
dc.date.available2025-01-24T00:04:12Z
dc.date.issued2013
dc.description.abstractTetrahydrohyperforin (IDN5706), a semi-synthetic derivative of hyperforin, has shown neuroprotective properties preventing the impairment of synaptic plasticity and cognitive decline in an in vivo model of Alzheimer's disease (AD). Considering the reported role of adult neurogenesis in the plasticity of the hippocampal network, we investigated whether IDN5706 affects adult neurogenesis and hippocampal function. In hippocampal progenitors cultured from adult rats, IDN5706 increased proliferation. Moreover, treatment with IDN5706 for 4 weeks increased cell proliferation in the subgranular zone (SGZ) of the hippocampus in 2 month-old wild-type mice in vivo. As determined by double labeling with BrdU and neuronal markers, IDN5706 treatment increased the number of immature neurons and newborn mature neurons in the adult dentate gyrus. In addition, IDN5706 treatment improved long-term memory in a hippocampal-dependent spatial memory task. Finally, IDN5706 treatment increased cell proliferation and neural commitment in the SGZ of the double transgenic APPswe/PS1 Delta E9 mouse model of AD. These results indicate that IDN5706 increases adult hippocampal neurogenesis and may have therapeutic value in neurological disorders in which adult neurogenesis is impaired.
dc.fuente.origenWOS
dc.identifier.doi10.3233/JAD-121714
dc.identifier.issn1387-2877
dc.identifier.urihttps://doi.org/10.3233/JAD-121714
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101797
dc.identifier.wosidWOS:000316464700007
dc.issue.numero4
dc.language.isoen
dc.pagina.final885
dc.pagina.inicio873
dc.revistaJournal of alzheimers disease
dc.rightsacceso restringido
dc.subjectAlzheimer's disease
dc.subjecthippocampus
dc.subjectlong-term memory
dc.subjectneural progenitor cells
dc.subjectneurogenesis
dc.subjecttetrahydrohyperforin
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTetrahydrohyperforin Increases Adult Hippocampal Neurogenesis in Wild-Type and APPswe/PS1 ΔE9 Mice
dc.typeartículo
dc.volumen34
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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