BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity

Simple item page
dc.contributor.authorGamell, Cristina
dc.contributor.authorOsses, Nelson
dc.contributor.authorBartrons, Ramon
dc.contributor.authorRueckle, Thomas
dc.contributor.authorCamps, Montserrat
dc.contributor.authorRosa, Jose Luis
dc.contributor.authorVentura, Francesc
dc.date.accessioned2025-01-21T01:04:56Z
dc.date.available2025-01-21T01:04:56Z
dc.date.issued2008
dc.description.abstractBone morphogenetic proteins (BMPs) are potent regulators of several cellular events. We report that exposure of C2C12 cells to BMP2 leads to an increase in cell migration and a rapid rearrangement of the actin filaments into cortical protrusions. These effects required independent and parallel activation of the Cdc42 small GTPase and the alpha-isoform of the phosphoinositide 3-kinase (PI3K alpha), because ectopic expression of a dominant-negative form of Cdc42 or distinct pharmacological PI3K inhibitors abrogated these responses. Furthermore, we demonstrate that BMP2 activates different group I and group II PAK isoforms as well as LIMK1 with similar kinetics to Cdc42 or PI3K activation. BMP2 activation of PAK and LIMK1, measured by either kinase activity or with antibodies raised against phosphorylated residues at their activation loops, were abolished by blocking PI3K-signaling pathways. Together, these findings suggest that Cdc42 and PI3K signals emanating from BMP receptors are involved in specific regulation of actin assembly and cell migration.
dc.fuente.origenWOS
dc.identifier.doi10.1242/jcs.031286
dc.identifier.eissn1477-9137
dc.identifier.issn0021-9533
dc.identifier.urihttps://doi.org/10.1242/jcs.031286
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95743
dc.identifier.wosidWOS:000261038200012
dc.issue.numero23
dc.language.isoen
dc.pagina.final3970
dc.pagina.inicio3960
dc.revistaJournal of cell science
dc.rightsacceso restringido
dc.subjectBMP
dc.subjectCell migration
dc.subjectActin cytoskeleton
dc.subjectPI3K
dc.subjectCdc42
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity
dc.typeartículo
dc.volumen121
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas