DOES CONTINUOUS POSITIVE AIRWAY PRESSURE (CPAP) DURING WEANING FROM INTERMITTENT MANDATORY VENTILATION IN VERY-LOW-BIRTH-WEIGHT INFANTS HAVE RISKS OR BENEFITS - A CONTROLLED TRIAL

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dc.contributor.authorTAPIA, JL
dc.contributor.authorBANCALARI, A
dc.contributor.authorGONZALEZ, A
dc.contributor.authorMERCADO, ME
dc.date.accessioned2025-01-21T01:34:50Z
dc.date.available2025-01-21T01:34:50Z
dc.date.issued1995
dc.description.abstractObjective: The purpose of this study was to evaluate three ventilator weaning strategies and to evaluate whether the use of continuous positive airway pressure (CPAP) via a nasopharyngeal or endotracheal tube would increase the likelihood of extubation failure in very low birth weight (VLBW) infants. Study design: We studied prospectively 87 preterm infants (mean +/- SD; birth weight: 1078 +/- 188 g; gestational age: 28.8 +/- 2.2 weeks) who were in the process of being weaned from intermittent mandatory ventilation (IMV). Infants were assigned by systematic sampling to one of the following three treatment groups: (1) direct extubation from IMV (D.EXT) (n=30); (2) preextubation endotracheal CPAP (ET-CPAP) for 12-24 hr (n=28); or (3) postextubation nasopharyngeal CPAP (NP-CPAP) for 12-24 hr (n=29). Failure was defined as the need for resumption of mechanical ventilation within 72 hr of extubation due to frequent or severe apnea and/or respiratory failure (pH < 7.25, PaCO2 > 60 mm Hg, and/or requirement for oxygen FiO(2) > 60%). Results: There were no significant differences in failure rates among the three procedures. Failures were 2/30 (7%) in D.EXT; 4/28 (14%) in ET-CPAP; and 7/29 (24%) in the NP-CPAP. There were also no differences in FiO(2), PaO2, and respiratory rates before and after discontinuation of IMV among the three groups. PaCO2 values were slightly higher in the NP-CPAP group 12-24 hr after weaning from IMV. Conclusion: We were unable to demonstrate a clear difference in extubation outcome by use of CPAP administered via an endotracheal or nasopharyngeal tube when compared to direct extubation from low-rate IMV in VLBW infants. (C) 1995 Wiley-Liss, Inc.
dc.fuente.origenWOS
dc.identifier.issn8755-6863
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97608
dc.identifier.wosidWOS:A1995RG32300004
dc.issue.numero5
dc.language.isoen
dc.pagina.final274
dc.pagina.inicio269
dc.revistaPediatric pulmonology
dc.rightsacceso restringido
dc.subjectMECHANICAL VENTILATION
dc.subjectEXTUBATION
dc.subjectCPAP
dc.subjectVLBW INFANTS
dc.subjectWEANING
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDOES CONTINUOUS POSITIVE AIRWAY PRESSURE (CPAP) DURING WEANING FROM INTERMITTENT MANDATORY VENTILATION IN VERY-LOW-BIRTH-WEIGHT INFANTS HAVE RISKS OR BENEFITS - A CONTROLLED TRIAL
dc.typeartículo
dc.volumen19
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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