INCREASED SECRETION OF ADRENAL PROGESTERONE EXPLAINS THE LACK OF RESPONSE OF OVIDUCTAL EMBRYO TRANSPORT TO A SHORT INTRAVENOUS-INFUSION OF ESTRADIOL IN THE RAT

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dc.contributor.authorMORAN, FM
dc.contributor.authorFORCELLEDO, ML
dc.contributor.authorCROXATTO, HB
dc.date.accessioned2025-01-23T19:22:58Z
dc.date.available2025-01-23T19:22:58Z
dc.date.issued1990
dc.description.abstractAdministration of estradiol (E2) as a single subcutaneous injection, but not as a short intravenous infusion (< 150 min), accelerates oviductal embryo transport in pregnant rats although the first mode determines lower E2 circulating levels. Since progesterone (P) can antagonize the effect of E2 on embryo transport we examined the circulating P levels under these two modes of E2 administration.
dc.description.abstractRats were treated on day 1 of pregnancy with 5-mu-g E2 given s.c. or i.v. (10 min infusion). Other groups were either hypophysectomized (HPX), adrenalectomized (ADX) or ovariectomized (OVX) prior to E2 treatment to prevent P rise, or were treated with E2 plus RU486 to block the action of P. Some groups were autopsied at short intervals following treatment to measure P levels and others 24 h later to assess the effect of treatments on embryo transport.
dc.description.abstractP was increased several fold by i.v. infusions of E2 or vehicle alone in intact and OVX rats but not in HPX or ADX rats, whereas s.c. administration of E2 did not change P levels unless it was given concomitantly with i.v. infusion of vehicle. The short i.v. infusion of E2 accelerated embryo transport in HPX, ADX, or RU486 treated rats but not in intact rats. The s.c. injection of E2 accelerated embryo transport even when it was accompanied by an i.v. infusion of vehicle.
dc.description.abstractThe data does not exclude the participation of glucocorticoids in the above phenomena but agrees with the view that it is the transient increase in adrenal P secretion which blunts the oviductal response to a brief pulse of E2.
dc.fuente.origenWOS
dc.identifier.issn0004-0533
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99138
dc.identifier.wosidWOS:A1990GN77100004
dc.issue.numero4
dc.language.isoen
dc.pagina.final305
dc.pagina.inicio299
dc.revistaArchivos de biologia y medicina experimentales
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleINCREASED SECRETION OF ADRENAL PROGESTERONE EXPLAINS THE LACK OF RESPONSE OF OVIDUCTAL EMBRYO TRANSPORT TO A SHORT INTRAVENOUS-INFUSION OF ESTRADIOL IN THE RAT
dc.typeartículo
dc.volumen23
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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