EFFECTS OF BETA-ENDORPHIN AND D-ALANINE2 ENKEPHALINAMIDE ON URINE PRODUCTION AND URINARY ELECTROLYTES IN THE RAT

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dc.contributor.authorHUIDOBROTORO, JP
dc.contributor.authorHUIDOBRO, F
dc.contributor.authorCROXATTO, R
dc.date.accessioned2025-01-23T19:44:43Z
dc.date.available2025-01-23T19:44:43Z
dc.date.issued1979
dc.description.abstractThe intracerebro-ventricular administration of human .beta.-Endorphin (.beta.-EP, 0.1-3 .mu.g/rat) or D-alanine2 methionine enkephalinamide (D-ala, 0.3-30 .mu.g/rat) caused a dose dependent reduction in urine volume. The oliguria was associated with a decrease in the concentration of Na+ and K+ in the urine of rats previously hydrated by oral administration with 25 ml/kg tap water plus 50 ml/kg 0.5% NaCl. On a molar basis, .beta.-EP proved to be about 5-7 times more potent than D-ala. The effects caused by the peptides were antagonized by simultaneous i.p. administration of 1 mg/kg naloxone. In rats treated chronically with morphine, no cross-tolerance was demonstrated to the antidiuretic effect of .beta.-EP, but clear cross-tolerance was evident to the changes in urine electrolytes induced by .beta.-EP. Morphine and the opiate peptides may share a similar mechanism of action.
dc.fuente.origenWOS
dc.identifier.eissn1879-0631
dc.identifier.issn0024-3205
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100108
dc.identifier.wosidWOS:A1979GK36000006
dc.issue.numero8
dc.language.isoen
dc.pagina.final703
dc.pagina.inicio697
dc.revistaLife sciences
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEFFECTS OF BETA-ENDORPHIN AND D-ALANINE2 ENKEPHALINAMIDE ON URINE PRODUCTION AND URINARY ELECTROLYTES IN THE RAT
dc.typeartículo
dc.volumen24
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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