FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors

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dc.contributor.authorLei, Xia
dc.contributor.authorLiu, Lili
dc.contributor.authorTerrillion, Chantelle E.
dc.contributor.authorKaruppagounder, Senthilkumar S.
dc.contributor.authorCisternas, Pedro
dc.contributor.authorLay, Mark
dc.contributor.authorMartinelli, David C.
dc.contributor.authorAja, Susan
dc.contributor.authorDong, Xinzhong
dc.contributor.authorPletnikov, Mikhail, V
dc.contributor.authorWong, G. William
dc.date.accessioned2025-01-23T21:09:14Z
dc.date.available2025-01-23T21:09:14Z
dc.date.issued2019
dc.description.abstractCytokines and chemokines play diverse roles in different organ systems. Family with sequence similarity 19, member A1-5 (FAM19A1-A5; also known as TAFA1-5) is a group of conserved chemokine-like proteins enriched in the CNS of mice and humans. Their functions are only beginning to emerge. Here, we show that the expression of Fam19a1-a5 in different mouse brain regions are induced or suppressed by unfed and refed states. The striking nutritional regulation of Fam19a family members in the brain suggests a potential central role in regulating metabolism. Using a knockout (KO) mouse model, we show that loss of FAM19A1 results in sexually dimorphic phenotypes. In male mice, FAM19A1 deficiency alters food intake patterns during the light and dark cycle. Fam19a1 KO mice are hyperactive, and locomotor hyperactivity is more pronounced in female KO mice. Behavior tests indicate that Fam19a1 KO female mice have reduced anxiety and sensitivity to pain. Spatial learning and exploration, however, is preserved in Fam19a1 KO mice. Altered behaviors are associated with elevated norepinephrine and dopamine turnover in the striatum. Our results establish an in vivo function of FAM19A1 and highlight central roles for this family of neurokines in modulating animal physiology and behavior.
dc.description.funderU.S. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
dc.fuente.origenWOS
dc.identifier.doi10.1096/fj.201901232RR
dc.identifier.eissn1530-6860
dc.identifier.issn0892-6638
dc.identifier.urihttps://doi.org/10.1096/fj.201901232RR
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100806
dc.identifier.wosidWOS:000507466100128
dc.issue.numero12
dc.language.isoen
dc.pagina.final14747
dc.pagina.inicio14734
dc.revistaFaseb journal
dc.rightsacceso restringido
dc.subjectchemokine-like
dc.subjectdopamine
dc.subjectlocomotor hyperactivity
dc.subjectTAFA1
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors
dc.typeartículo
dc.volumen33
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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