Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model

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dc.contributor.authorMedina, Rafael
dc.contributor.authorTapia, Rodrigo.
dc.contributor.authorGarcía, Victoria.
dc.contributor.authorMena, Juan.
dc.contributor.authorBucarey Vivanco, Sergio.
dc.contributor.authorNeira, Víctor.
dc.date.accessioned2019-10-17T13:56:42Z
dc.date.available2019-10-17T13:56:42Z
dc.date.issued2018
dc.date.updated2019-10-14T19:08:08Z
dc.description.abstractAbstract Novel H1N2 and H3N2 swine influenza A viruses (IAVs) were identified in commercial farms in Chile. These viruses contained H1, H3 and N2 sequences, genetically divergent from IAVs described worldwide, associated with pandemic internal genes. Guinea pigs were used as human surrogate to evaluate the infection dynamics of these reassortant viruses, compared with a pandemic H1N1 virus. All viruses replicated and were shed in the upper respiratory tract without prior adaptation although H1N2 viruses showed the highest shedding titers. This could have public health importance, emphasizing the need to carry out further studies to evaluate the zoonotic potential of these viruses.Abstract Novel H1N2 and H3N2 swine influenza A viruses (IAVs) were identified in commercial farms in Chile. These viruses contained H1, H3 and N2 sequences, genetically divergent from IAVs described worldwide, associated with pandemic internal genes. Guinea pigs were used as human surrogate to evaluate the infection dynamics of these reassortant viruses, compared with a pandemic H1N1 virus. All viruses replicated and were shed in the upper respiratory tract without prior adaptation although H1N2 viruses showed the highest shedding titers. This could have public health importance, emphasizing the need to carry out further studies to evaluate the zoonotic potential of these viruses.Abstract Novel H1N2 and H3N2 swine influenza A viruses (IAVs) were identified in commercial farms in Chile. These viruses contained H1, H3 and N2 sequences, genetically divergent from IAVs described worldwide, associated with pandemic internal genes. Guinea pigs were used as human surrogate to evaluate the infection dynamics of these reassortant viruses, compared with a pandemic H1N1 virus. All viruses replicated and were shed in the upper respiratory tract without prior adaptation although H1N2 viruses showed the highest shedding titers. This could have public health importance, emphasizing the need to carry out further studies to evaluate the zoonotic potential of these viruses.Abstract Novel H1N2 and H3N2 swine influenza A viruses (IAVs) were identified in commercial farms in Chile. These viruses contained H1, H3 and N2 sequences, genetically divergent from IAVs described worldwide, associated with pandemic internal genes. Guinea pigs were used as human surrogate to evaluate the infection dynamics of these reassortant viruses, compared with a pandemic H1N1 virus. All viruses replicated and were shed in the upper respiratory tract without prior adaptation although H1N2 viruses showed the highest shedding titers. This could have public health importance, emphasizing the need to carry out further studies to evaluate the zoonotic potential of these viruses.
dc.fuente.origenBiomed Central
dc.identifier.citationVeterinary Research. 2018 Jul 27;49(1):73
dc.identifier.doi10.1186/s13567-018-0572-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26658
dc.identifier.wosidWOS:000440186400001
dc.issue.numeroNo. 73
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final8
dc.pagina.inicio1
dc.revistaVeterinary Researches_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.subject.otherMicrobiología médicaes_ES
dc.subject.otherVirologíaes_ES
dc.subject.otherEnfermedades infecciosases_ES
dc.subject.otherImmunologíaes_ES
dc.titleInfection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig modeles_ES
dc.typeartículo
dc.volumenVol. 49
sipa.codpersvinculados1000649
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