Molecular and Phylogenomic Analysis of a Vancomycin Intermediate Resistance USA300LV Strain in Chile

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dc.contributor.authorNunez, Daniela
dc.contributor.authorJimenez, Pablo
dc.contributor.authorMartin, Marcelo Cortez-San
dc.contributor.authorCortes, Carolina
dc.contributor.authorCardenas, Matias
dc.contributor.authorMichelson, Sofia
dc.contributor.authorGaray, Tamara
dc.contributor.authorVecchiola, Maggie
dc.contributor.authorCespedes, Alejandra
dc.contributor.authorMaldonado, Jonathan E.
dc.contributor.authorVasquez-Martinez, Yesseny
dc.date.accessioned2025-01-20T16:12:16Z
dc.date.available2025-01-20T16:12:16Z
dc.date.issued2024
dc.description.abstractAntimicrobial resistance is a major global health problem, and, among Gram-positive bacteria, methicillin-resistant Staphylococcus aureus (MRSA) represents a serious threat. MRSA causes a wide range of infections, including bacteremia, which, due to the limited use of beta-lactams, is difficult to treat. This study aimed to analyze 51 MRSA isolates collected in 2018 from samples of patients with bacteremia from two hospitals of the Metropolitan Health Service of Santiago, Chile, both in their resistance profile and in the identification of virulence factors. In addition, genomic characterization was carried out by the WGS of an isolate that was shown to be the one of greatest concern (N degrees. 42) due to its intermediate resistance to vancomycin, multiple virulence factors and being classified as ST8 PVL-positive. In our study, most of the isolates turned out to be multidrug-resistant, but there are still therapeutic options, such as tetracycline, rifampicin, chloramphenicol and vancomycin, which are currently used for MRSA infections; however, 18% were PVL positive, which suggests greater virulence of these isolates. It was determined that isolate N degrees 42 is grouped within the USA300-LV strains (ST8, PVL+, COMER+); however, it has been suggested that, in Chile, a complete displacement of the PVL-negative ST5 clone has not occurred.
dc.fuente.origenWOS
dc.identifier.doi10.3390/microorganisms12071284
dc.identifier.eissn2076-2607
dc.identifier.urihttps://doi.org/10.3390/microorganisms12071284
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90323
dc.identifier.wosidWOS:001277245700001
dc.issue.numero7
dc.language.isoen
dc.revistaMicroorganisms
dc.rightsacceso restringido
dc.subjectMRSA
dc.subjectantibiotic resistance
dc.subjectmolecular characterization
dc.subjectWGS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMolecular and Phylogenomic Analysis of a Vancomycin Intermediate Resistance USA300LV Strain in Chile
dc.typeartículo
dc.volumen12
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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