DHA Supplementation during Pregnancy in Women with Obesity Normalizes IGF2R Levels in the Placenta of Male Newborns

Simple item page
dc.contributor.authorCastro, Juan Jose
dc.contributor.authorUmana-Perez, Adriana
dc.contributor.authorCastano-Moreno, Erika
dc.contributor.authorCasanello, Paola
dc.contributor.authorRonco, Ana Maria
dc.date.accessioned2025-01-20T20:09:22Z
dc.date.available2025-01-20T20:09:22Z
dc.date.issued2023
dc.description.abstractIntroduction. Insulin-like growth factor receptor 2 (IGF2R) regulates placental nutrient transport, and its soluble form is related to obesity in adults. If the placental expression of IGF2R is altered in women with obesity is unknown. Whether maternal supplementation with docosahexaenoic acid (DHA), a polyunsaturated fatty acid with anti-inflammatory properties, has a modulatory role in IGF2R's function has not been elucidated. We hypothesized that maternal obesity (Ob) would be associated with alterations in placental IGF2R expression, which may be prevented with DHA supplementation during pregnancy. Methods. At delivery, we obtained placentas from women with Ob (BMI & GE; 30 kg/m(2), n = 17), Ob supplemented with 800 mg/day of DHA during pregnancy (Ob + DHA, n = 13), and normal-weight women (Nw, BMI & GE; 18.5 & LE; 24.9 kg/m(2), n = 14). The IGF2R mRNA and protein were determined by RT-PCR and western blotting, respectively. Moreover, we quantified the gene expression of molecules that modulate the IGF2R function in the extracellular domain, such as TACE/ADAM17, PLAU, and IGF2. Mann-Whitney and Kruskal-Wallis nonparametric tests were used to compare results between two or three groups accordingly. Results. The IGF2R levels in the Ob placentas of the male offspring were higher than in the Nw group. The DHA supplementation prevented this effect, suggesting an unknown relationship between IGF2R-Ob-DHA in placental tissues. Conclusion. We report, for the first time, that DHA supplementation during pregnancy in women with obesity normalizes the increased IGF2R levels in male placentas, reducing the risk of adverse outcomes related to the IGF2/IGF2R system in male newborns.
dc.fuente.origenWOS
dc.identifier.doi10.1155/2023/1515033
dc.identifier.eissn1687-8345
dc.identifier.issn1687-8337
dc.identifier.urihttps://doi.org/10.1155/2023/1515033
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91990
dc.identifier.wosidWOS:001024501000001
dc.language.isoen
dc.revistaInternational journal of endocrinology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleDHA Supplementation during Pregnancy in Women with Obesity Normalizes IGF2R Levels in the Placenta of Male Newborns
dc.typeartículo
dc.volumen2023
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas