Treatment of older patients with multiple sclerosis: Results of an International Delphi Survey

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dc.contributor.authorTumani, Hayrettin
dc.contributor.authorCoyle, Patricia K.
dc.contributor.authorCarcamo, Claudia
dc.contributor.authorCordioli, Cinzia
dc.contributor.authorLopez, Pablo A.
dc.contributor.authorPeterka, Marek
dc.contributor.authorRamo-Tello, Cristina
dc.contributor.authorZuluaga, Maria, I
dc.contributor.authorKoster, Thijs
dc.contributor.authorVignos, Megan
dc.date.accessioned2025-01-20T17:27:19Z
dc.date.available2025-01-20T17:27:19Z
dc.date.issued2023
dc.description.abstractBackgroundPeople over age 50-55 have historically been excluded from randomized clinical trials for multiple sclerosis (MS). However, more than half of those living with an MS diagnosis are over 55.ObjectiveExplore the unique considerations of treating older people with MS (PwMS) using an iterative and structured Delphi-based assessment to gather expert opinions.MethodsEight MS neurologists with an interest in older PwMS developed a 2-round survey. Survey respondents were qualified neurologists with >= 3 years' experience, personally responsible for treatment decisions, and treating >= 20 patients per month, of whom >= 10% were >= 50 years old. Consensus was defined as >= 75% agreement on questions with categorical responses or as a mean score >= 4 on questions with numerical responses.ResultsIn Survey 1, 224 neurologists responded; 180 of these completed Survey 2. Limited consensus was reached with varying levels of agreement on several topics including identification and assessment of older patients; factors relating to treatment decisions including immunosenescence and comorbidities; considerations for high-efficacy treatments; de-escalation or discontinuation of treatment; effects of COVID-19; and unmet needs for treating this population.ConclusionThe results of this Delphi process highlight the need for targeted studies to create guidance for the care of older PwMS.
dc.description.funderLuke Ward, PhD, of Ashfield MedComms (Middletown, CT, USA), an Inizio Company, assisted with drafting the manuscript, and Celia Nelson, also of Ashfield MedComms, copyedited, styled, the manuscript per journal requirements, and aided with submission.
dc.fuente.origenWOS
dc.identifier.doi10.1177/20552173231198588
dc.identifier.eissn2055-2173
dc.identifier.urihttps://doi.org/10.1177/20552173231198588
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91566
dc.identifier.wosidWOS:001093076700001
dc.issue.numero3
dc.language.isoen
dc.revistaMultiple sclerosis journal-experimental translational and clinical
dc.rightsacceso restringido
dc.subjectMultiple sclerosis
dc.subjectconsensus
dc.subjectstandards
dc.subjectDelphi technique
dc.subjectolder patients
dc.subjecttreatment recommendations
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTreatment of older patients with multiple sclerosis: Results of an International Delphi Survey
dc.typeartículo
dc.volumen9
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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