Does perchlorate in drinking water affect thyroid function in newborns or school-age children?

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dc.contributor.authorCrump, C
dc.contributor.authorMichaud, P
dc.contributor.authorTellez, R
dc.contributor.authorReyes, C
dc.contributor.authorGonzalez, G
dc.contributor.authorMontgomery, EL
dc.contributor.authorCrump, KS
dc.contributor.authorLobo, G
dc.contributor.authorBecerra, C
dc.contributor.authorGibbs, JP
dc.date.accessioned2025-01-21T01:31:22Z
dc.date.available2025-01-21T01:31:22Z
dc.date.issued2000
dc.description.abstractPerchlorate is known to suppress thyroid function by inhibiting uptake of iodide by the human thyroid at doses of 200 mg/day or greater. A study was conducted to investigate the potential effects of perchlorate in drinking water on thyroid function in newborns and school-age children. A total of 162 school-age children and 9784 newborns were studied in three proximate cities in northern Chile that have different concentrations of perchlorate in drinking water: Taltal (100 to 120 mu g/L), Chanaral (5 to 7 mu g/L), and Antofagasta (non-detectable: <4 mu g/L). Among schoolchildren, no difference was found in thyroid-stimulating hormone levels or goiter prevalence among lifelong residents of Taltal or Chanaral compared with those of Antofagasta, after adjusting for age, sex, and urinary iodine. No presumptive cases of congenital hypothyroidism were detected in Taltal or Chanaral; seven cases were detected in Antofagasta. Neonatal thyroid-stimulating hormone levels were significantly lower in Taltal compared with Antofagasta; this is opposite to the known pharmacological effect of perchlorate, and the magnitude of difference did not seem to be clinically significant. These findings do not support the hypothesis that perchlorate in drinking water at concentrations as high as 100 to 120 mu g/L suppresses thyroid function in newborns or school-age children.
dc.fuente.origenWOS
dc.identifier.eissn1536-5948
dc.identifier.issn1076-2752
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97047
dc.identifier.wosidWOS:000087706300008
dc.issue.numero6
dc.language.isoen
dc.pagina.final612
dc.pagina.inicio603
dc.revistaJournal of occupational and environmental medicine
dc.rightsacceso restringido
dc.subject.ods06 Clean Water and Sanitation
dc.subject.odspa06 Agua limpia y saneamiento
dc.titleDoes perchlorate in drinking water affect thyroid function in newborns or school-age children?
dc.typeartículo
dc.volumen42
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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