Association of the estrogen receptor α gene polymorphisms with osteoporosis in the Mexican population

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dc.contributor.authorGomez, R.
dc.contributor.authorMagana, J. J.
dc.contributor.authorCisneros, B.
dc.contributor.authorPerez-Salazar, E.
dc.contributor.authorFaugeron, S.
dc.contributor.authorVeliz, D.
dc.contributor.authorCastro, C.
dc.contributor.authorRubio, J.
dc.contributor.authorCasas, L.
dc.contributor.authorValdes-Flores, Margarita
dc.date.accessioned2025-01-21T01:05:19Z
dc.date.available2025-01-21T01:05:19Z
dc.date.issued2007
dc.description.abstractThe estrogen receptor gene (ER alpha) has been implicated in the development of osteoporosis. In this study, the association of two ER alpha gene polymorphic markers (a TA dinucleotide repeat and a single nucleotide polymorphism, G2014A) with osteoporosis was tested in 70 osteoporotic women, 70 non-osteoporotic women and 500 subjects from the Mexican population. According to the genetic analysis of the Mexican population using eight unlinked polymorphic markers, we found that our population is structured into three subpopulations; therefore, the allele-phenotype relationship was analyzed with a statistical method that considered population stratification. We found that the G2014A polymorphism is associated with the presence of osteoporosis while the TA dinucleotide repeat is not. The G allele and the GG genotype frequencies of the G2014A marker were significantly higher in osteoporotic than in non-osteoporotic women. Likewise, subjects bearing the G allele in heterozygous or homozygous displayed lower values for lumbar bone mineral density and T score than those who did not present any G allele. The effect of confounders for osteoporosis on the association of G allele-osteoporosis was ruled out. In summary, we conclude that the G2014 polymorphism may become a useful marker for genetic studies of osteoporosis in the Mexican population.
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1399-0004.2007.00898.x
dc.identifier.eissn1399-0004
dc.identifier.issn0009-9163
dc.identifier.urihttps://doi.org/10.1111/j.1399-0004.2007.00898.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95889
dc.identifier.wosidWOS:000250915800015
dc.issue.numero6
dc.language.isoen
dc.pagina.final581
dc.pagina.inicio574
dc.revistaClinical genetics
dc.rightsacceso restringido
dc.subjectbone mineral density
dc.subjectdinucleotide polymorphism
dc.subjectestrogen receptor alpha gene
dc.subjectosteoporosis
dc.subjectsingle nucleotide polymorphism
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation of the estrogen receptor α gene polymorphisms with osteoporosis in the Mexican population
dc.typeartículo
dc.volumen72
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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