MULTIDRUG RESISTANCE GENE AND P-GLYCOPROTEIN EXPRESSION IN GASTRIC ADENOCARCINOMA AND PRECURSOR LESIONS

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dc.contributor.authorVOLLRATH, V
dc.contributor.authorCHIANALE, J
dc.contributor.authorGONZALEZ, S
dc.contributor.authorDUARTE, I
dc.contributor.authorANDRADE, L
dc.contributor.authorIBANEZ, L
dc.date.accessioned2025-01-23T19:22:54Z
dc.date.available2025-01-23T19:22:54Z
dc.date.issued1991
dc.description.abstractOverexpression of the Multiple Drug Resistance gene (MDR1) has been proposed as a major mechanism related to both intrinsic and acquired resistance to chemotherapeutic agents. The gene product is a membrane protein (P-glycoprotein), that acts as an energy-dependent drug efflux pump decreasing drug accumulation in resistant tumor cells. We have characterized MDR1 and P-Glycoprotein expression in human gastric adenocarcinoma and in precursor lesions. MDR1 mRNAs, analyzed by dot-blot technique, were detected in 9 of 10 non-tumoral gastric mucoase and in 8 of 10 gastric adenocarcinomas. Immunohistochemical analysis, using the MRK16 monoclonal antibody, revealed heterogeneous expression of P-Glycoprotein in individual cells. The P-Glycoprotein was found on the surface of cells of gastric areas with intenstinal metaplasia subtype III. This type of intestinal metaplasia, also called "colonic metaplasia", has been strongly associated with a high risk for the development of gastric cancer. The fact that the P-Glycoprotein was detected in this precursor lesion is consistent with the intestinal metaplasiadysplasia and carcinoma sequence proposed in the histogenesis of this tumor. The finding that P-Glycoprotein was heterogeneously expressed in malignant cells of some gastric adenocarcinomas also suggests that this transporter system probably contributes to primary and secondary multidrug resistance in this neoplasm.
dc.fuente.origenWOS
dc.identifier.issn0340-6075
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99125
dc.identifier.wosidWOS:A1991FG96000009
dc.issue.numero2
dc.language.isoen
dc.pagina.final138
dc.pagina.inicio133
dc.revistaVirchows archiv b-cell pathology including molecular pathology
dc.rightsacceso restringido
dc.subjectMULTIDRUG RESISTANCE GENE
dc.subjectP-GLYCOPROTEIN
dc.subjectGASTRIC CANCER
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMULTIDRUG RESISTANCE GENE AND P-GLYCOPROTEIN EXPRESSION IN GASTRIC ADENOCARCINOMA AND PRECURSOR LESIONS
dc.typeartículo
dc.volumen60
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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