KINETICS OF PLATELET DENSITY SUBPOPULATIONS IN SPLENECTOMIZED MONGREL DOGS

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dc.contributor.authorMEZZANO, D
dc.contributor.authorARANDA, E
dc.contributor.authorFORADORI, A
dc.contributor.authorRODRIGUEZ, S
dc.contributor.authorLIRA, P
dc.date.accessioned2025-01-23T19:43:51Z
dc.date.available2025-01-23T19:43:51Z
dc.date.issued1984
dc.description.abstractAutologous 51Cr-platelet kinetic studies were performed in splenectomized mongrel dogs. Mean survival time of PRP[platelet-rich plasma]-platelets was 5.4 .+-. 1.5 (SD) days (n = 6). The curves, though slightly curvilinear, showed mostly a linear type of decay, denoting that platelet removal from the circulation is mainly determined by aging of the cells. High-density (HD) and low-density (LD) platelet cohorts were isolated in Stractan gradients from samples drawn daily after infusion of labeled platelets. Specific radioactivity in HD cohorts declined rapidly postinfusion (T1/2 [half-life] = 1.3 days), but specific radioactivity in LD platelets increased for 2 days and steadily declined for 4 days thereafter (n = 6). Labeled HD platelets, comprising 11.7% of the total population, lived significantly longer in circulation than LD platelets (19.1% of the total population) (n = 3). The patterns of decay of the radioactivity do not have all the characteristics of pure age-cohort survival curves; 3.7 days after the infusion of labeled HD platelets, the specific radioactivity in LD cohorts was 6 times higher than on day 1, but attained only 20% of the initial specific radioactivity in HD platelets. After the infusion of labeled LD platelets no radioactivity was recovered in circulating HD cohorts. Mongrel dog platelets apparently decrease in density with aging, but also platelet density heterogeneity is in part determined during the thrombopoietic process. These data are consistent with those of other authors in rabbits and rhesus monkeys, but contrast with the observations that platelets in humans, baboons and Macaca fasicularis monkeys increase in density with age, suggesting that the displacement of platelets toward compartments of either higher or lower density depends on the species under study.
dc.fuente.origenWOS
dc.identifier.eissn1096-8652
dc.identifier.issn0361-8609
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99841
dc.identifier.wosidWOS:A1984TQ67600006
dc.issue.numero4
dc.language.isoen
dc.pagina.final382
dc.pagina.inicio373
dc.revistaAmerican journal of hematology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleKINETICS OF PLATELET DENSITY SUBPOPULATIONS IN SPLENECTOMIZED MONGREL DOGS
dc.typeartículo
dc.volumen17
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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