Autologous fibroblasts for the treatment of cutaneous loxoscelism: First experience

Simple item page
dc.contributor.authorGuglielmetti, Antonio
dc.contributor.authorJahr, Catalina
dc.contributor.authorGompertz-Mattar, Matias
dc.date.accessioned2025-01-23T21:11:05Z
dc.date.available2025-01-23T21:11:05Z
dc.date.issued2019
dc.description.abstractSeveral treatments have been described for cutaneous loxoscelism (CL), but the quality of available evidence is insufficient for the elaboration of a therapeutic consensus. Dapsone has shown beneficial effects on stopping the inflammatory phenomenon and accelerating the recovery. It is recommended to start dapsone once the visceral involvement is ruled out if glucose-6-phosphate dehydrogenase levels are normal. Autologous fibroblast (AF) therapy is a novel therapy that has been successfully used in bioengineering as skin substitutes for surgical wounds and burns, diabetic and pressure ulcers, and other aesthetic purposes. Interestingly, there are no reports of AFs in CL. We present a case of CL in which the necrotic process was stabilised with dapsone, but the healing of the ulcer was not achieved. Three weekly applications of AFs 100 000/cm(2) were performed on a biocompatible polymer matrix, with optimal response within 2 months. This represents the first report of AFs in CL, setting the stage for future studies.
dc.fuente.origenWOS
dc.identifier.doi10.1111/iwj.13222
dc.identifier.eissn1742-481X
dc.identifier.issn1742-4801
dc.identifier.urihttps://doi.org/10.1111/iwj.13222
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100882
dc.identifier.wosidWOS:000486744200001
dc.issue.numero6
dc.language.isoen
dc.pagina.final1505
dc.pagina.inicio1503
dc.revistaInternational wound journal
dc.rightsacceso restringido
dc.subjectautologous fibroblasts
dc.subjectcellular therapy
dc.subjectdapsone
dc.subjectloxoscelism
dc.subjectskin regeneration
dc.titleAutologous fibroblasts for the treatment of cutaneous loxoscelism: First experience
dc.typeartículo
dc.volumen16
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas