Differential effects of polysulphates between mouse and hamster during <i>in vitro</i> fertilization

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dc.contributor.authorMoreno, RD
dc.contributor.authorOrihuela, PA
dc.contributor.authorBarros, C
dc.date.accessioned2025-01-21T01:31:00Z
dc.date.available2025-01-21T01:31:00Z
dc.date.issued2001
dc.description.abstractThe interaction between zona pellucida polysulphates and sperm receptors appears to be a widespread mechanism used by mammals during gamete interaction. In this work, the effect of hepar in on binding, penetration and fertilization of mouse and hamster oocytes was assessed. We found that heparin inhibited oocyte penetration and fertilization in both species. Heparin as well as fucoidan (a fucose-sulphate polymer) inhibited the proteolytic: activity of acrosomal enzymes in both species. Our results suggest that zona pellucida penetration in both species may be modulated by polysulphates acting on either the proteolytic rate of degradation of the zona and/or its interaction with acrosome-reacted sperm (secondary binding).
dc.fuente.origenWOS
dc.identifier.eissn1439-0272
dc.identifier.issn0303-4569
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96957
dc.identifier.wosidWOS:000167106300003
dc.issue.numero1
dc.language.isoen
dc.pagina.final25
dc.pagina.inicio19
dc.revistaAndrologia
dc.rightsacceso restringido
dc.subjectacrosome
dc.subjectheparin oocyte
dc.subjectspermatozoon
dc.subjectzona pellucida
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDifferential effects of polysulphates between mouse and hamster during <i>in vitro</i> fertilization
dc.typeartículo
dc.volumen33
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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