Peroxisomal proliferation protects from β-amyloid neurodegeneration

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dc.contributor.authorSantos, M.J.
dc.contributor.authorQuintanilla, R.A.
dc.contributor.authorToro, A.S.
dc.contributor.authorGrandy, R.
dc.contributor.authorDinamarca, M.C.
dc.contributor.authorGodoy, J.A.
dc.contributor.authorInestrosa, N.C.
dc.date.accessioned2025-01-21T01:06:33Z
dc.date.available2025-01-21T01:06:33Z
dc.date.issued2005
dc.description.abstractAlzheimer disease is a neurodegenerative process that leads to severe cognitive impairment as a consequence of selective death of neuronal populations. The molecular pathogenesis of Alzheimer disease involves the participation of the beta-amyloid peptide (A beta) and oxidative stress. We report here that peroxisomal proliferation attenuated A beta-dependent toxicity in hippocampal neurons. Pretreatment with Wy-14.463 (Wy), a peroxisome proliferator, prevent the neuronal cell death and neuritic network loss induced by the A beta peptide. Moreover, the hippocampal neurons treated with this compound, showed an increase in the number of peroxisomes, with a concomitant increase in catalase activity. Additionally, we evaluate the Wy protective effect on beta-catenin levels, production of intracellular reactive oxygen species, cytoplasmic calcium uptake, and mitochondrial potential in hippocampal neurons exposed to H2O2 and A beta peptide. Results show that the peroxisomal proliferation prevents beta-catenin degradation, reactive oxygen species production, cytoplasmic calcium increase, and changes in mitochondrial viability. Our data suggest, for the first time, a direct link between peroxisomal proliferation and neuroprotection from A beta-induced degenerative changes.
dc.fechaingreso.objetodigital2025-07-21
dc.fuente.origenWOS
dc.identifier.doi10.1074/jbc.M505160200
dc.identifier.eissn1083-351X
dc.identifier.urihttps://doi.org/10.1074/jbc.M505160200
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96180
dc.identifier.wosidWOS:000233666600080
dc.issue.numeroNo. 49
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final41068
dc.pagina.inicio41057
dc.revistaJournal of Biological Chemistry
dc.rightsacceso abierto
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePeroxisomal proliferation protects from β-amyloid neurodegeneration
dc.typeartículo
dc.volumenVol. 280
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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