SLOW AXOPLASMIC-TRANSPORT - A FICTION

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dc.contributor.authorALVAREZ, J
dc.contributor.authorTORRES, JC
dc.date.accessioned2025-01-23T19:27:40Z
dc.date.available2025-01-23T19:27:40Z
dc.date.issued1985
dc.description.abstractRibosomes have not been observed in axoplasm. This had led to the notions that the perikaryon is the only source of neuronal proteins and that the axoplasm is supplied by a (slow) transport mechanism. These 2 notions were questioned because they are unable to give an account of real neurones in accordance with the body of biological knowledge. For example, the synthetic rate of perikarya or the life span of axoplasmic proteins should be beyond known ranges for animal cells and a uniform axon is unlikely to result if it is fed from one end. An alternative view was proposed for the maintenance of the axon which accepts the controversial idea of axoplasmic synthesis of proteins; as a result, the slow transport becomes unnecessary. This view gives a qualitative account of the observations dealing with the maintenance of the axoplasm. To account for the phenomenology in a more quantitative fashion, a computer simulation was carried out where the equations of the program provided only for axoplasmic synthesis of proteins; the set of curves retrieved were in good agreement with experimental findings believed so far to support the notion of slow transport. The notion of slow axoplasmic transport has been a misinterpretation of good observations because the frame of reference was incomplete in not providing for axoplasmic synthesis of proteins.
dc.fuente.origenWOS
dc.identifier.eissn1095-8541
dc.identifier.issn0022-5193
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99754
dc.identifier.wosidWOS:A1985ABR7400016
dc.issue.numero3
dc.language.isoen
dc.pagina.final651
dc.pagina.inicio627
dc.revistaJournal of theoretical biology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSLOW AXOPLASMIC-TRANSPORT - A FICTION
dc.typeartículo
dc.volumen112
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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