Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type <i>Octodon degu</i>
| dc.contributor.author | Inestrosa, NC | |
| dc.contributor.author | Reyes, AE | |
| dc.contributor.author | Chacón, MA | |
| dc.contributor.author | Cerpa, W | |
| dc.contributor.author | Villalón, A | |
| dc.contributor.author | Montiel, J | |
| dc.contributor.author | Merabachvili, G | |
| dc.contributor.author | Aldunate, R | |
| dc.contributor.author | Bozinovic, F | |
| dc.contributor.author | Aboitiz, F | |
| dc.date.accessioned | 2025-01-21T01:06:52Z | |
| dc.date.available | 2025-01-21T01:06:52Z | |
| dc.date.issued | 2005 | |
| dc.description.abstract | It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal beta-amyloid precursor protein (beta-APP695) displaying both intracellular and extracellular deposits of amyloid-beta-peptide (A beta), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. The high amino acid homology (97.5%) between deguA beta and humanA beta sequences is probably a major factor in the appearance of AD markers in this aged rodent. Our results indicate that aged 0. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD. (c) 2004 Elsevier Inc. All rights reserved. | |
| dc.fuente.origen | WOS | |
| dc.identifier.doi | 10.1016/j.neurobiolaging.2004.09.016 | |
| dc.identifier.eissn | 1558-1497 | |
| dc.identifier.issn | 0197-4580 | |
| dc.identifier.uri | https://doi.org/10.1016/j.neurobiolaging.2004.09.016 | |
| dc.identifier.uri | https://repositorio.uc.cl/handle/11534/96236 | |
| dc.identifier.wosid | WOS:000227821000007 | |
| dc.issue.numero | 7 | |
| dc.language.iso | en | |
| dc.pagina.final | 1028 | |
| dc.pagina.inicio | 1023 | |
| dc.revista | Neurobiology of aging | |
| dc.rights | acceso restringido | |
| dc.subject | Alzheimer's disease | |
| dc.subject | Alzheimer model | |
| dc.subject | neuropathology | |
| dc.subject | amyloid- beta-peptide | |
| dc.subject | APP | |
| dc.subject | Octodon degu | |
| dc.subject.ods | 03 Good Health and Well-being | |
| dc.subject.odspa | 03 Salud y bienestar | |
| dc.title | Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type <i>Octodon degu</i> | |
| dc.type | artículo | |
| dc.volumen | 26 | |
| sipa.index | WOS | |
| sipa.trazabilidad | WOS;2025-01-12 |