Complete remission of non-HIV collapsing glomerulopathy with deflazacort and lisinopril in an adult patient

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dc.contributor.authorVega, Jorge
dc.contributor.authorJavier Guarda, Francisco
dc.contributor.authorGoecke, Helmuth
dc.contributor.authorMendez, Gonzalo P.
dc.date.accessioned2025-01-21T00:05:14Z
dc.date.available2025-01-21T00:05:14Z
dc.date.issued2010
dc.description.abstractCollapsing glomerulopathy is a form of focal segmental glomerulosclerosis that is usually associated with HIV-1 infection, and is characterized by its poor prognosis and almost inevitable progression to end-stage renal disease. Its pathological features include collapsed glomeruli, podocyte hypertrophy and hyperplasia, and pseudocrescents. This case report shows the evolution of a 58-year-old patient with non-HIV idiopathic collapsing glomerulopathy who presented with severe nephrotic syndrome and renal insufficiency and was treated with lisinopril and deflazacort, a synthetic corticosteroid that has shown fewer cosmetic effects and glucose and bone metabolism complications than prednisone. The patient responded with full recovery of renal function and normal range of protein excreted in urine after less than two years of treatment. The patient has not suffered a recurrence of his nephrotic syndrome after three years of steroid withdrawal. There is no proven therapy for collapsing glomerulopathy, and this case highlights an alternative for treating this disease with few secondary effects.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s10157-010-0284-1
dc.identifier.eissn1437-7799
dc.identifier.issn1342-1751
dc.identifier.urihttps://doi.org/10.1007/s10157-010-0284-1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95539
dc.identifier.wosidWOS:000280594100013
dc.issue.numero4
dc.language.isoen
dc.pagina.final388
dc.pagina.inicio385
dc.revistaClinical and experimental nephrology
dc.rightsacceso restringido
dc.subjectCollapsing glomerulopathy
dc.subjectNephrotic syndrome
dc.subjectDeflazacort
dc.subjectLisinopril
dc.subjectFocal segmental glomerulosclerosis
dc.subjectChronic kidney diseases
dc.subjectRenal insufficiency
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleComplete remission of non-HIV collapsing glomerulopathy with deflazacort and lisinopril in an adult patient
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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