Procedural and clinical benefits of selective thrombus aspiration in primary PCI. Insights from the TAPER Registry

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dc.contributor.authorJurado-Roman A.
dc.contributor.authorAbellan J.
dc.contributor.authorLopez-Lluva M.T.
dc.contributor.authorSanchez-Perez I.
dc.contributor.authorLozano F.
dc.contributor.authorMontero-Cabezas J.M.
dc.contributor.authorSchalij M.J.
dc.contributor.authorMartinez G.
dc.contributor.authorFuensalida A.
dc.contributor.authorde Nicolas J.M.M.
dc.contributor.authorde Labriolle A.
dc.date.accessioned2024-01-10T14:22:47Z
dc.date.available2024-01-10T14:22:47Z
dc.date.issued2019
dc.description.abstract© 2019 Permanyer Publications. All rights reserved.Introduction and objectives: After the results of several randomized trials, routine thrombus aspiration (TA) has remained out of the spotlight after not improving the prognosis of patients with ST-segment elevation myocardial infarction and even increasing their complications. The goal here was to assess the impact of selective TA during primary percutaneous coronary intervention (pPCI), its safety and clinical benefits at 1-year follow-up. Methods: The TAPER registry (efficacy and safety of selective Thrombus Aspiration in Real clinical Practice) retrospectively included patients with ST-segment elevation myocardial infarction treated with pPCI. The clinical and procedural characteristics and the composite endpoint of cardiovascular mortality, non-fatal myocardial infarction, stent thrombosis, target lesion revascularization or stroke were evaluated after at 1-year follow-up. Results: 687 patients (76.9% males, 64 ± 12 years) were analyzed. The TA was performed in 40.3% of cases (in 89.9% as the initial strategy and in 10.1% as the bailout strategy) and it was successful in 93.8% of them. The most important predictor of TA use was a higher initial Thrombolysis in Myocardial Infarction (TIMI) thrombus grade (OR, 3.2; 95%CI, 2.5-3.9; P < .0001). TA achieved a significant improvement of TIMI-flow (2.4 points) and a significant reduction of the TIMI thrombus grade (2.6 points). At 1-year follow-up, no stroke was observed in the TA-group and the rate of the composite endpoint (cardiovascular mortality, non-fatal myocardial infarction, stent thrombosis, target lesion revascularization or stroke) was similar in both groups (TA-group 8% vs non-TA-group 5.7%; P = .24). Conclusions: Selective TA is frequently used in the current clinical practice with a high success rate and a low rate of associated complications. It significantly reduces thrombotic burden and improves coronary flow. At 1-year follow-up, a similar rate of adverse events was observed regardless of the use of TA.
dc.fechaingreso.objetodigital2024-05-22
dc.fuente.origenScopus
dc.identifier.doi10.24875/RECICE.M19000043
dc.identifier.eissn26047322
dc.identifier.issn26047322 26047306
dc.identifier.scopusidSCOPUS_ID:85089276323
dc.identifier.urihttps://doi.org/10.24875/RECICE.M19000043
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80003
dc.identifier.wosidWOS:000908939100007
dc.information.autorucFacultad de Medicina; Fuenzalida Alarcon, Alberto Javier; S/I; 209476
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final182
dc.pagina.inicio175
dc.publisherPermanyer Publications
dc.revistaREC: Interventional Cardiology
dc.rightsacceso abierto
dc.subjectPrimary PCI
dc.subjectSTEMI
dc.subjectThrombus aspiration
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleProcedural and clinical benefits of selective thrombus aspiration in primary PCI. Insights from the TAPER Registry
dc.typeartículo
dc.volumen1
sipa.codpersvinculados209476
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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