Aumento de intoxicaciones intencionales por paracetamol en Chile (2019-2023): Estudio del Centro de Información Toxicológica UC

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dc.catalogadorvzp
dc.contributor.authorIturra Montecinos, Pablo Andrés
dc.contributor.authorSilva Silva, Lorena Alejandra
dc.contributor.authorBettini Silva, Marli Francesca
dc.contributor.authorMedel Jara, Patricio Andrés
dc.contributor.authorSolari Gajardo, Sandra
dc.contributor.authorRíos Bustamante, Juan Carlos
dc.date.accessioned2025-05-12T17:37:13Z
dc.date.available2025-05-12T17:37:13Z
dc.date.issued2025
dc.description.abstractParacetamol (acetaminophen) is one of the most widely used analgesics and antipyretics in the world. It's easy acquisition, however, has frequently involved it in accidental and intentional poisonings, which, depending on the dose ingested, could lead to liver damage. To counteract this problem, several countries and agencies have regulated the sale and use of paracetamol. Even so, recent studies have shown an increase in suicidal intoxications using paracetamol or other drugs, especially since the COVID-19 pandemic. Aim: Characterize the variation in the number of paracetamol poisonings in Chile, registered by the Poison Control Center of the Pontifical Catholic University of Chile (CITUC), during the last 5 years. Methods: Observational study of the calls for cases of paracetamol ingestion, admitted to CITUC, between 2019 and 2023. Results: eleven thousand thirty-nine cases of paracetamol exposure were recorded, where 68.8% of these were related to suicidal ideation. This type of poisoning showed an 11% increase as of 2020. Female patients accounted for 80.3% of the cases of paracetamol ingestion for suicidal purposes, while in 56.6% of the cases of suicidal ideation, the patients reached potentially hepatotoxic doses of paracetamol. Conclusions: Paracetamol poisoning with suicidal intent has progressively and significantly increased in Chile since the onset of the coronavirus pandemic. It is therefore necessary to replicate and implement preventive measures used by other countries to reduce poisonings related to this drug, in addition to taking steps to optimize the management of these cases.
dc.fechaingreso.objetodigital2025-05-12
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/s0034-98872025000200085
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.urihttps://doi.org/10.4067/s0034-98872025000200085
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104141
dc.identifier.wosidWOS:001445063300002
dc.information.autorucEscuela de Medicina; Iturra Montecinos, Pablo Andrés; S/I; 1025306
dc.information.autorucEscuela de Medicina; Silva Silva, Lorena Alejandra; S/I; 1007809
dc.information.autorucEscuela de Medicina; Bettini Silva, Marli Francesca; S/I; 9918
dc.information.autorucEscuela de Medicina; Medel Jara, Patricio Andres; S/I; 187147
dc.information.autorucEscuela de Medicina; Solari Gajardo, Sandra; 0000-0002-3185-4717; 1871
dc.information.autorucEscuela de Medicina; Ríos Bustamante, Juan Carlos; 0000-0003-0701-9604; 104168
dc.issue.numero2
dc.language.isoes
dc.nota.accesocontenido completo
dc.pagina.final95
dc.pagina.inicio85
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCentros de Control de Intoxicaciones
dc.subjectIdeación suicida
dc.subjectIntoxicaciones
dc.subjectParacetamol
dc.titleAumento de intoxicaciones intencionales por paracetamol en Chile (2019-2023): Estudio del Centro de Información Toxicológica UC
dc.title.alternativeIncrease in intentional paracetamol poisoning in Chile (2019-2023): A study from the UC Toxicology Information Center
dc.typeartículo
dc.volumen153
sipa.codpersvinculados1025306
sipa.codpersvinculados1007809
sipa.codpersvinculados9918
sipa.codpersvinculados187147
sipa.codpersvinculados1871
sipa.codpersvinculados104168
sipa.trazabilidadWOS;2025-03-29
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