Nuclear Receptors, Inflammation, and Liver Disease: Insights for Cholestatic and Fatty Liver Diseases

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dc.contributor.authorArrese, M.
dc.contributor.authorKarpen, S. J.
dc.date.accessioned2025-01-21T00:06:13Z
dc.date.available2025-01-21T00:06:13Z
dc.date.issued2010
dc.description.abstractMembers of the nuclear receptor (NR) superfamily of ligand-activated transcription factors are players of substantial relevance in the regulation of hepatic gene expression. NRs direct normal physiology and metabolism, adaptations to liver disease, and responses to inflammation and toxins. They also contribute to the regenerative response. In this review, we summarize currently available experimental and clinical data, focusing on the role of NRs in cholestasis and nonalcoholic fatty liver disease (NAFLD). We also highlight the potential of NRs as targets for safe and effective therapeutic interventions.
dc.fuente.origenWOS
dc.identifier.doi10.1038/clpt.2010.2
dc.identifier.eissn1532-6535
dc.identifier.issn0009-9236
dc.identifier.urihttps://doi.org/10.1038/clpt.2010.2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95580
dc.identifier.wosidWOS:000276506900022
dc.issue.numero4
dc.language.isoen
dc.pagina.final478
dc.pagina.inicio473
dc.revistaClinical pharmacology & therapeutics
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNuclear Receptors, Inflammation, and Liver Disease: Insights for Cholestatic and Fatty Liver Diseases
dc.typeartículo
dc.volumen87
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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