Nanostructure-Driven Indocyanine Green Dimerization Generates Ultra-Stable Phototheranostics Nanoparticles

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dc.contributor.authorKwon, Nahyun
dc.contributor.authorJasinevicius, Gabriel O.
dc.contributor.authorKassab, Giulia
dc.contributor.authorDing, Lili
dc.contributor.authorBu, Jiachuan
dc.contributor.authorMartinelli, Leticia P.
dc.contributor.authorFerreira, Vinicius G.
dc.contributor.authorDhaliwal, Alexander
dc.contributor.authorChan, Harley H. L.
dc.contributor.authorMo, Yulin
dc.contributor.authorBagnato, Vanderlei S.
dc.contributor.authorKurachi, Cristina
dc.contributor.authorChen, Juan
dc.contributor.authorZheng, Gang
dc.contributor.authorBuzza, Hilde H.
dc.date.accessioned2025-01-20T20:10:51Z
dc.date.available2025-01-20T20:10:51Z
dc.date.issued2023
dc.description.abstractIndocyanine green (ICG) is the only near-infrared (NIR) dye approved for clinical use. Despite its versatility in photonic applications and potential for photothermal therapy, its photobleaching hinders its application. Here we discovered a nanostructure of dimeric ICG (Nano-dICG) generated by using ICG to stabilize nanoemulsions, after which ICG enabled complete dimerization on the nanoemulsion shell, followed by J-aggregation of ICG-dimer, resulting in a narrow, red-shifted (780 nm -> 894 nm) and intense (approximate to 2-fold) absorbance. Compared to ICG, Nano-dICG demonstrated superior photothermal conversion (2-fold higher), significantly reduced photodegradation (-9.6 % vs. -46.3 %), and undiminished photothermal effect (7 vs. 2 cycles) under repeated irradiations, in addition to excellent colloidal and structural stabilities. Following intravenous injection, Nano-dICG enabled real-time tracking of its delivery to mouse tumors within 24 h by photoacoustic imaging at NIR wavelength (890 nm) distinct from the endogenous signal to guide effective photothermal therapy. The unprecedented finding of nanostructure-driven ICG dimerization leads to an ultra-stable phototheranostic platform.
dc.fuente.origenWOS
dc.identifier.doi10.1002/anie.202305564
dc.identifier.eissn1521-3773
dc.identifier.issn1433-7851
dc.identifier.urihttps://doi.org/10.1002/anie.202305564
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92100
dc.identifier.wosidWOS:000998595700001
dc.issue.numero28
dc.language.isoen
dc.revistaAngewandte chemie-international edition
dc.rightsacceso restringido
dc.subjectIndocyanine Green
dc.subjectNanoemulsion
dc.subjectPhotoacoustic Imaging
dc.subjectPhotostability
dc.subjectPhotothermal Therapy
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNanostructure-Driven Indocyanine Green Dimerization Generates Ultra-Stable Phototheranostics Nanoparticles
dc.typeartículo
dc.volumen62
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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