Lung oxidative stress as related to exercise and altitude.: Lipid peroxidation evidence in exhaled breath condensate

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dc.contributor.authorAraneda, OF
dc.contributor.authorGarcía, C
dc.contributor.authorLagos, N
dc.contributor.authorQuiroga, G
dc.contributor.authorCajigal, J
dc.contributor.authorSalazar, MP
dc.contributor.authorBehn, C
dc.date.accessioned2025-01-21T01:06:36Z
dc.date.available2025-01-21T01:06:36Z
dc.date.issued2005
dc.description.abstractLung oxidative stress (OS) was explored in resting and in exercising subjects exposed to moderate and high altitude. Exhaled breath condensate (EBC) was collected under field conditions in male high-competition mountain bikers performing a maximal cycloergometric exercise at 670 m and at 2,160 m, as well as, in male soldiers climbing up to 6,125 m in Northern Chile. Malondialdehyde concentration [MDA] was measured by high-performance liquid chromatography in EBC and in serum samples. Hydrogen peroxide concentration [H2O2] was analysed in EBC according to the spectrophotometric FOX2 assay. [MDA] in EBC of bikers did not change while exercising at 670 m, but increased from 30.0 +/- 8.0 to 50.0 +/- 11.0 nmol l(-1) (P < 0.05) at 2,160 m. Concomitantly, [MDA] in serum and [H2O2] in EBC remained constant. On the other hand, in mountaineering soldiers, [H2O2] in EBC under resting conditions increased from 0.30 +/- 0.12 mu mol l(-1) stop at 670 m to 1.14 +/- 0.29 mu mol l(-1) stop immediately on return from the mountain. Three days later, [H2O2] in EBC (0.93 +/- 0.23 mu mol l(-1) stop) continued to be elevated (P < 0.05). [MDA] in EBC increased from 71 +/- 16 nmol l(-1) stop at 670 m to 128 +/- 26 nmol l(-1) stop at 3,000 m (P < 0.05). Changes of [H2O2] in EBC while ascending from 670 m up to 3,000 m inversely correlated with concomitant variations in HbO2 saturation (r=-0.48, P < 0.05). AMS score evaluated at 5,000 m directly correlated with changes of [MDA] in EBC occurring while the subjects moved from 670 to 3,000 m (r=0.51, P < 0.05). Lung OS may constitute a pathogenic factor in AMS.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00421-005-0047-y
dc.identifier.eissn1439-6327
dc.identifier.issn1439-6319
dc.identifier.urihttps://doi.org/10.1007/s00421-005-0047-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96189
dc.identifier.wosidWOS:000233468100001
dc.issue.numero5-6
dc.language.isoen
dc.pagina.final390
dc.pagina.inicio383
dc.revistaEuropean journal of applied physiology
dc.rightsacceso restringido
dc.subjectexhaled breath condensate
dc.subjectlung oxidative stress
dc.subjectphysical exercise
dc.subjecthypobaric hypoxia
dc.subjectacute mountain sickness
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLung oxidative stress as related to exercise and altitude.: Lipid peroxidation evidence in exhaled breath condensate
dc.typeartículo
dc.volumen95
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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