Clinical-epidemiological analysis of infections in pediatric patients with liver and heart trasplants

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dc.catalogadorjwg
dc.contributor.authorJung Montanares, Francisca Andrea
dc.contributor.authorAstudillo Paredes, Patricio Andrés
dc.contributor.authorVrsalovic Papic, Katica Ivanka
dc.contributor.authorRosales Alfaro, Valentina José
dc.contributor.authorMarinovic, Nicole L'Huillier
dc.contributor.authorVizcaya Altamirano, María Cecilia
dc.contributor.authorFerres Garrido, Marcela Viviana
dc.contributor.authorUrcelay Montecinos, Gonzalo Eduardo
dc.contributor.authorGana Ansaldo, Juan Cristobál
dc.contributor.authorAbarca Villaseca, Katia
dc.date.accessioned2025-03-13T19:31:42Z
dc.date.available2025-03-13T19:31:42Z
dc.date.issued2024
dc.description.abstractBackground: Liver and heart transplantation represents the definitive treatment for end-stage failure of these organs. In recent years, an increasing number of pediatric patients have undergone these procedures, which are associated with various complications. Among them, infections stand out as one of the main causes of morbidity and mortality. Aim: To describe the infections that affect pediatric recipients of liver and heart transplants (Tx.). Methods: A characterization of the type and timing of infections identified in 31 children who underwent heart transplantation and 27 who underwent liver transplantation at a tertiary university hospital since 2002 (cardiac Tx) and 2009 (hepatic Tx), both to 2022 is presented. Results: Biliary atresia and dilated cardiomyopathy were the main reasons for liver and heart transplantation, respectively. Bacterial infections predominated during the first month after these surgical procedures, while viral infections predominated later. Bacterial infections in general, and bacteriemia were more common in liver Tx. recipients. Cytomegalovirus (CMV) and Epstein-Barr virus, mainly in the form of reactivations, were the most frequently identified viruses, with a higher frequency of CMV in liver Tx. recipients. One patient from each group died in a late period due to bacterial sepsis, without a specific agent identified. Conclusion: The preponderance of infections due to latent viral agents, such as CMV, in pediatric liver or heart transplant recipients, reveals the need to optimize the management of these infections in this growing population in Chile.
dc.fuente.origenORCID
dc.identifier.doi10.4067/s0716-10182024000400136
dc.identifier.eissn0717-6341
dc.identifier.issn0716-1018
dc.identifier.urihttps://doi.org/10.4067/s0716-10182024000400136
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102585
dc.identifier.wosidWOS:001354413500007
dc.information.autorucEscuela de Medicina; Astudillo Paredes, Patricio Andrés; S/I; 179203
dc.information.autorucEscuela de Medicina; Vrsalovic Papic, Katica Ivanka; S/I; 246279
dc.information.autorucEscuela de Medicina; Jung Montanares, Francisca Andrea; S/I; 1072948
dc.information.autorucEscuela de Medicina; Rosales Alfaro, Valentina José; S/I; 233304
dc.information.autorucEscuela de Medicina; Abarca Villaseca, Katia; 0000-0003-0404-3887; 70281
dc.information.autorucEscuela de Medicina; Urcelay Montecinos, Gonzalo Eduardo; S/I; 57478
dc.information.autorucEscuela de Medicina; Vizcaya Altamirano, María Cecilia; 0000-0003-1309-9778; 7645
dc.information.autorucEscuela de Medicina; Ferres Garrido, Marcela Viviana; 0000-0001-9415-4657; 66180
dc.information.autorucEscuela de Medicina; Gana Ansaldo, Juan Cristobál; 0000-0002-0400-2164; 8726
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final534
dc.pagina.inicio523
dc.publisherSOC CHILENA INFECTOLOGIA
dc.revistaREVISTA CHILENA DE INFECTOLOGIA
dc.rightsacceso restringido
dc.subjectpediatrics
dc.subjectheart
dc.subjectliver
dc.subjecttransplant
dc.subjectinfections
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical-epidemiological analysis of infections in pediatric patients with liver and heart trasplants
dc.typeartículo
dc.volumen41
sipa.codpersvinculados179203
sipa.codpersvinculados246279
sipa.codpersvinculados1072948
sipa.codpersvinculados233304
sipa.codpersvinculados70281
sipa.codpersvinculados57478
sipa.codpersvinculados7645
sipa.codpersvinculados66180
sipa.codpersvinculados8726
sipa.trazabilidadORCID;2025-03-03
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