Exposure to pesticides in Chile and its relationship with carcinogenic potential: a review

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dc.article.number1531751
dc.catalogadorvzp
dc.contributor.authorMunoz-Quezada, María Teresa
dc.contributor.authorIglesias, Verónica
dc.contributor.authorZúñiga-Venegas, Liliana
dc.contributor.authorPancetti, Floria
dc.contributor.authorFoerster, Claudia
dc.contributor.authorLanderos, Natalia
dc.contributor.authorLucero, Boris
dc.contributor.authorSchwantes, Daniel
dc.contributor.authorCortes Arancibia, Sandra Isabel
dc.date.accessioned2025-05-12T17:54:53Z
dc.date.available2025-05-12T17:54:53Z
dc.date.issued2025
dc.description.abstractBackground: The widespread application of pesticides in agriculture and the consequent heightened human exposure to these potentially harmful substances present considerable environmental and health risks. The potential link to cancer is particularly concerning, underscoring the urgent need for more sustainable and health-conscious agricultural practices. Pesticides are pervasive global contaminants, with exposure occurring through various routes. Improper use is associated with genotoxicity, neurobehavioral problems, thyroid dysfunction, reproductive issues, and cancer, among other deleterious damages. While pesticide exposure is evident in Chile, a direct link to cancer remains uncertain. Objective: To examine the scientific evidence on pesticides exposure in the environment and human populations, and its relationship with cancer in Chilean territory. Methods: The search for original articles was performed in international peer-reviewed scientific databases, including Scopus, Web of Science (WoS), and PubMed Advanced Search Builder. Following the PRISMA extension for review guidelines, the search included studies on environmental pesticide exposure, human biomarker assessments, experimental investigations, and the potential pesticide-cancer associations in Chile. Foreign studies, systematic reviews, and meta-analyses were excluded. Results: Among the 83 qualifying studies conducted between 1996 and 2024, elevated pesticide exposure risks were documented, with 71% indicating high concentrations that may pose health risk. Additionally, 20% of studies reported significant chlorinated compounds, including organochlorines (OCs) and polychlorinated biphenyls (PCBs), while 79.5% identified carcinogenic to humans classified by the International Agency for Research on Cancer. The review emphasizes the urgent need to update pesticide-related regulations in Chile, including implementing bans or restrictions on carcinogenic pesticides and establishing stricter standards for allowable pesticide residue levels in food. Conclusion: Long-term epidemiological studies are essential to establishing concrete links between pesticide exposure and specific types of cancer. Additionally, investigating epigenetic markers associated with pesticide exposure, especially in occupational settings, is critical. Furthermore, allocating resources and prioritizing further research is fundamental, particularly in regions with substantial agricultural exposure.
dc.fechaingreso.objetodigital2025-05-12
dc.format.extent20 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.3389/fpubh.2025.1531751
dc.identifier.issn2296-2565
dc.identifier.scopusidSCOPUS_ID:105002611846
dc.identifier.urihttp://dx.doi.org/10.3389/FPUBH.2025.1531751
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104142
dc.information.autorucFacultad de Agronomía e Ingeniería Forestal; Schwantes, Daniel; 0000-0002-2251-5887; 1095189
dc.information.autorucEscuela de Medicina; Cortes Arancibia, Sandra Isabel; 0000-0003-3293-1419; 1005970
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherFrontiers Media SA
dc.revistaFrontiers in Public Health
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCarcinogenic effects
dc.subjectEnvironmental contamination
dc.subjectGenotoxicity
dc.subjectHealth risk assessment
dc.subjectPesticide exposure
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExposure to pesticides in Chile and its relationship with carcinogenic potential: a review
dc.typeartículo de revisión
dc.volumen13
sipa.codpersvinculados1095189
sipa.codpersvinculados1005970
sipa.trazabilidadSCOPUS;2025-04-20
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