Cross-species transmission and PB2 mammalian adaptations of highly pathogenic avian influenza A/H5N1 viruses in Chile

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dc.catalogadorgjm
dc.contributor.authorPardo Roa, Catalina
dc.contributor.authorNelson, Martha I.
dc.contributor.authorAriyama, Naomi
dc.contributor.authorAguayo, Carolina
dc.contributor.authorAlmonacid Cárdenas, Leonardo Iván
dc.contributor.authorMuñoz, Gabriela
dc.contributor.authorNavarro, Carlos
dc.contributor.authorÁvila, Claudia
dc.contributor.authorUlloa, Mauricio
dc.contributor.authorReyes, Rodolfo
dc.contributor.authorFuentes Luppichini, Eugenia Lucía Angélica
dc.contributor.authorMathieu, Christian
dc.contributor.authorVergara, Ricardo
dc.contributor.authorGonzález, Álvaro
dc.contributor.authorGonzález, Carmen Gloria
dc.contributor.authorAraya, Hugo
dc.contributor.authorFernández, Jorge
dc.contributor.authorFasce, Rodrigo
dc.contributor.authorJohow, Magdalena
dc.contributor.authorMedina, Rafael
dc.contributor.authorNeira, Víctor
dc.date.accessioned2025-06-27T14:45:00Z
dc.date.available2025-06-27T14:45:00Z
dc.date.issued2023
dc.description.abstractH5N1 highly pathogenic avian influenza viruses (HPAIV) emerged in wild birds in Chile in December 2022 and spilled over into poultry, marine mammals, and one human. Between December 9, 2022 – March 14, 2023, a coordinated government/academic response detected HPAIV by real-time RT-PCR in 8.5% (412/4735) of samples from 23 avian and 3 mammal orders. Whole-genome sequences obtained from 77 birds and 8 marine mammals revealed that all Chilean H5N1 viruses belong to lineage 2.3.4.4b and cluster monophyletically with viruses from Peru, indicating a single introduction from North America into Peru/Chile. Mammalian adaptations were identified in the PB2 segment: D701N in two sea lions, one human, and one shorebird, and Q591K in the human and one sea lion. Minor variant analysis revealed that D701N was present in 52.9 – 70.9% of sequence reads, indicating the presence of both genotypes within hosts. Further surveillance of spillover events is warranted to assess the emergence and potential onward transmission of mammalian adapted H5N1 HPAIV in South America.
dc.fechaingreso.objetodigital2025-06-27
dc.format.extent36 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1101/2023.06.30.547205
dc.identifier.urihttps://doi.org/10.1101/2023.06.30.547205
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104781
dc.information.autorucFacultad de Ciencias Biológicas; Pardo Roa, Catalina; 0000-0002-5409-225X; 225251
dc.information.autorucFacultad de Ciencias Biológicas; Almonacid Cárdenas, Leonardo Iván; S/I; 250112
dc.information.autorucEscuela de Medicina; Medina, Rafael; 0000-0002-5013-6884; 1000649
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistabioRxiv
dc.rightsacceso abierto
dc.rights.licenseCC0 1.0 Universal
dc.rights.urihttps://creativecommons.org/publicdomain/zero/1.0/
dc.subjectH5N1
dc.subjectHPAIV
dc.subjectPanzootic
dc.subjectMarine Mammals
dc.subjectChile
dc.subjectGenomic Surveillance
dc.subjectInterspecies transmission
dc.subjectZoonotic
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.ods14 Life below water
dc.subject.odspa14 Vida submarina
dc.titleCross-species transmission and PB2 mammalian adaptations of highly pathogenic avian influenza A/H5N1 viruses in Chile
dc.typepreprint
sipa.codpersvinculados225251
sipa.codpersvinculados250112
sipa.codpersvinculados1000649
sipa.trazabilidadORCID;2025-06-23
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